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Table 3 Uni- and multivariate Cox regression analyses for clinical characteristics and DKK-1 serum levels on overall survival in patients with prostate cancer

From: High serum levels of Dickkopf-1 are associated with a poor prognosis in prostate cancer patients

Variables

Univariate analyses

Multivariate analyses

 

HR

95% CI

P value

HR

95% CI

P value

Age (years)

1.04

0.96-1.13

0.34

not included

  

pT (pT3/4 vs. pT2)

11.30

2.64-48.45

0.001

8.76

1.85-41.47

0.006

pN (pN1 vs. pN0)

2.89

1.19-7.01

0.02

  

n.s.

Gleason

7.22

2.51-20.75

<0.001

3.34

1.10-10.29

0.036

PSA (ng/ml)

0.99

0.96-1.04

0.93

not included

  

DKK-1 (high vs. low)

3.01

1.18-7.63

0.02

3.73

1.44-9.66

0.007

  1. Abbreviations: CI = confidence interval; HR = hazard ratio.