Conventional chromosome analysis. A) Distribution of chromosome number per cell in LG and HG samples. B) Examples of chromatin and chromosome instability in different metaphases. Chromatin degeneration (a) and chromosome rearrangements: in particular, rearrangements of chromosome Y (b), 12 (c), 4 (d) and 1 (e). Examples of metaphases with chromosome Y rearrangements: clonal rea in the same metaphase (f, arrows) or clonal rea in different metaphases from the same patient (g, i). Example of different rea in the same metaphase (h).