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Table 5 Comparative analysis of the clinical characteristics of hepatocellular carcinoma patients with different miR-499 genotypes

From: High-resolution melting analysis reveals genetic polymorphisms in MicroRNAs confer hepatocellular carcinoma risk in Chinese patients

Characteristic

Reference intervals

TT (n = 195)

CT + CC (n = 119)

P

Alanine amiotransferase (U/L)a

0-46

38.0 (28.0, 66.0)

39.5 (28.3, 90.3)

0.470

Aspartate aminotransferase, (U/L)a

0-46

44.0 (30.0, 68.0)

47.0 (32.3, 90.3)

0.385

Total bilirubin (μmol/L)a

0-25

18.7 (13.3, 25.4)

19.1 (14.3, 27.9)

0.615

Direct bilirubin (μmol/L)a

0-7

4.7 (3.4, 6.6)

5.5 (4.1, 8.5)

0.031

Indirect bilirubin (μmol/L)a

1.5-18

13.9 (9.7,1 8.6)

14.2 (10.0, 19.1)

0.965

Total protein (g/L)a

60-80

68.0 (61.5, 73.2)

68.6 (63.6, 74.1)

0.307

Albumin (g/L)b

35-55

40.4 ± 6.2

39.8 ± 5.5

0.378

Globulin (g/L)a

20-30

27.1 (23.5, 30.3)

29.1 (24.9, 32.1)

0.034

Albumin/Globulina

1.5-2.5

1.5 (1.3, 1.7)

1.4 (1.3, 1.7)

0.099

γ-glutamyltransferase (U/L)a

5-55

55.0 (40.0, 99.0)

73.0 (37.0, 191.0)

0.022

Alkaline phosphatase (U/L)a

35-134

92.0 (74.0, 120.0)

108.5 (84.5, 136.8)

0.002

5-Nucleotidase (U/L)a

0-10

3.0 (2.0, 5.0)

3.0 (2.0, 7.5)

0.236

Total biliary acid (μmol/L)a

0-15

6.9 (3.5, 13.9)

9.3 (4.5, 19.4)

0.149

Cholinesterase (U/L)a

3000-10500

6264.2 ± 2351.8

5645.5 ± 2225.7

0.028

Pre-albumin (mg/L)a

100-400

125.5 (69.7, 168.9)

100.0 (70.0, 176.3)

0.374

Glucose (mmol/L)a

3.9-6.2

5.0 (4.5, 5.8)

5.2 (4.7, 5.9)

0.085

Blood urea nitrogen (mmol/L)a

1.7-7.2

5.0 (3.5, 5.8)

5.1 (3.9, 6.4)

0.187

Creatinine (μmol/L)a

45-117

73.8 (65.5, 84.0)

73.8 (61.9, 83.7)

0.187

Uric acid (μmol/L)b

119-417

252.0 ± 87.4

256.9 ± 87.3

0.642

Retinol-binding protein (mg/L)a

15-70

28.0 (17.9, 34.6)

27.9 (15.9, 38.2)

0.695

Cystatin C (mg/L)a

0-1.2

1.1 (0.9, 1.2)

1.0 (0.9, 1.3)

0.782

Carcinoembryonic antigen,(ng/mL)a

0-5

2.1 (1.4, 3.4)

2.3 (1.6, 1.9)

0.365

Alpha-fetoprotein (ng/mL)a

0-20

181.7 (10.9, 1000.0)

99.2 (8.4, 691.2)

0.164

Ferritin (ng/mL)a

0-322

196.8 (126.7, 361.2)

277.9 (161.0, 424.6)

0.212

Cancer antigen 125 (KU/L)a

0-35

15.2 (10.1, 31.7)

16.0 (8.6, 45.5)

0.707

Cancer antigen 153 (KU/L)a

0-35

10.4 (7.6, 14.1)

9.6 (7.3, 14.3)

0.720

Cancer antigen 199 (KU/L)a

0-35

13.3 (7.1, 23.7)

12.4 (6.6, 26.8)

0.585

Prothrombin time (sec)a

10.5-13.5

12.0 (11.3, 12.8)

11.9 (10.9, 13.2)

0.875

PT% (%)a

80-130

91.3 (82.0, 104.0)

93.5 (79.8, 109.0)

0.744

International standard ratioa

0.85-1.15

1.0 (1.0, 1.1)

1.0 (1.0, 1.2)

0.815

D-fibrinogen (g/L)a

2-4

2.7 (2.2, 3.4)

2.6 (2.3, 3.3)

0.724

activated partial thrombo-plastin time (sec)b

28-40

34.8 ± 7.3

34.3 ± 7.9

0.568

Thrombin time (sec)a

11-14

14.4 (13.8, 15.5)

14.5 (13.5, 15.5)

0.886

  1. aData were expressed as median (25th percentile, 75th percentile).
  2. bData were expressed as mean ± SD.