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Table 2 The association of selected risk factors with time between diagnosis and major resection, early stage colorectal cancer, 1996-2009

From: The association of time between diagnosis and major resection with poorer colorectal cancer survival: a retrospective cohort study

Variable

Time between diagnosis and resection (days)

Univariable analysis

Multivariable analysis1

 

Median

IQR

Coef2

95% Confidence interval

Coef2

95% Confidence interval

Age group

          

  15 – 44

26

(15–37)

0.00

   

0.00

   

  45 – 54

29

(17–41)

2.07

0.97

to

3.17

1.72

0.60

to

2.85

  55 – 64

30

(19–42)

3.59

2.46

to

4.72

2.92

1.76

to

4.08

  65 – 74

31

(19–43)

3.91

2.80

to

5.02

3.76

2.58

to

4.93

  75 and older

30

(16–43)

2.91

1.57

to

4.26

3.48

2.32

to

4.63

Gender

          

  Male

31

(19–43)

0.00

       

  Female

29

(16–41)

-1.87

-2.30

to

-1.44

-1.24

-1.54

to

-0.94

Region of residence

          

  London

28

(17–40)

0.00

       

  North East

30

(19–41)

1.55

-1.67

to

4.76

1.83

0.93

to

2.73

  North West

27

(13–41)

-1.07

-3.19

to

1.06

-2.21

-3.00

to

-1.43

  Yorkshire and the Humber

29

(18–42)

1.39

-0.73

to

3.52

1.50

0.65

to

2.36

  East Midlands

34

(21–46)

4.12

1.98

to

6.25

2.86

2.05

to

3.68

  West Midlands

32

(20–43)

3.04

0.91

to

5.16

2.16

1.37

to

2.95

  East of England

34

(23–45)

5.10

2.19

to

8.01

3.34

2.41

to

4.27

  South East

32

(19–43)

2.26

-0.76

to

5.28

1.87

-0.38

to

4.12

  South West

27

(11–40)

-2.21

-4.34

to

-0.08

-2.39

-3.19

to

-1.59

Ethnicity, major groups 3

          

  White

33

(21–43)

0.00

       

  Black

30

(21–42)

-0.60

-4.95

to

3.75

0.57

-2.97

to

4.11

  Asian

32

(20–41)

-0.92

-2.94

to

1.10

-0.66

-2.52

to

1.19

  Mixed

26

(17–35)

-6.26

-10.43

to

-2.09

-4.30

-8.40

to

-0.20

  Other Ethnic Group

30

(18–40)

-2.94

-6.44

to

0.55

-2.15

-4.99

to

0.68

  Unknown

34

(22–44)

0.47

-0.39

to

1.33

0.27

-0.80

to

1.34

Site

          

  Colon

28

(15–40)

0.00

       

  Rectosigmoid

32

(21–43)

4.48

3.61

to

5.35

4.42

3.81

to

5.03

  Rectum

36

(23–48)

7.68

5.85

to

9.52

7.57

6.10

to

9.04

Stage

          

  A

35

(23–46)

0.00

       

  B

28

(15–41)

-5.83

-6.25

to

-5.41

-4.12

-4.46

to

-3.77

Morphology

          

  Adenocarcinoma

30

(18–42)

0.00

       

  Mucinous adenocarcinoma

28

(14–40)

-2.45

-3.26

to

-1.64

-0.84

-1.44

to

-0.25

  Other

32

(18–43)

1.00

-0.16

to

2.16

1.18

0.23

to

2.12

  Not otherwise specified

28.5

(8–39)

        

Grade

          

  G1

28

(15–41)

0.00

       

  G2

30

(18–42)

1.81

0.67

to

2.94

1.16

0.27

to

2.06

  G3

28

(15–41)

0.15

-1.11

to

1.40

0.66

-0.29

to

1.62

  G4

20.5

(6–33)

-7.82

-12.76

to

-2.88

-6.45

-11.02

to

-1.88

  Unknown

29

(13–43)

        

Deprivation quintile 4

          

  1 - least deprived

31

(19–43)

0.00

       

  2

31

(19–43)

-0.11

-0.62

to

0.41

0.28

-0.55

to

1.11

  3

31

(19–43)

-0.07

-0.67

to

0.52

0.40

-0.29

to

1.09

  4

31

(18–43)

-0.33

-1.04

to

0.38

0.19

-0.55

to

0.93

  5 - most deprived

30

(17–42)

-0.52

-1.84

to

0.80

0.21

-0.55

to

0.98

  Unknown

21

(9–35)

        

Cancer plan implementation period

          

  Prior to implementation

24

(12–37)

0.00

       

  Initialization

29

(16–42)

4.23

3.09

to

5.37

4.83

3.56

to

6.10

  Implementation

33

(22–44)

7.06

4.10

to

10.01

8.02

5.53

to

10.51

  1. 1adjusted for all the other variables in the table except ethnicity.
  2. 2coefficient - represents the additional days between diagnosis and first resection for each category compared to the reference category.
  3. 3represents only data from 2005–2009.
  4. 4based on the income component of the 2007 Index of Multiple Deprivation.
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