Table 3 GO-analysis of 44 signature genes
From: Concerted down-regulation of immune-system related genes predicts metastasis in colorectal carcinoma
Biological process GO ID | P-value | Odds ratio | Ex-pected | Count | Size | GO Term | Associated gene symbols |
|---|---|---|---|---|---|---|---|
GO:0006955 | 1.4E-12 | 31.69 | 1.04 | 13 | 620 | Immune response | HLA-DMA, HLA-DPB1, HLA-DRB4, HLA-DRB5, IGHA1, IGLL1, IDO1, CXCL9, CCL18, CXCL11, BNIP3, CD86, CD74 |
GO:0002376 | 4.6E-12 | 26.94 | 1.47 | 14 | 874 | Immune system process | HLA-DMA, HLA-DPB1, HLA-DRB4, HLA-DRB5, IGHA1, IGLL1, IDO1, CXCL9, ORM1, CCL18, CXCL11, BNIP3, CD86, CD74 |
GO:0002504 | 1.8E-08 | 208.89 | 0.03 | 4 | 18 | Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | HLA-DMA, HLA-DPB1, HLA-DRB4, HLA-DRB5 |
GO:0019882 | 3.5E-08 | 73.05 | 0.10 | 5 | 58 | Antigen processing and presentation | HLA-DMA, HLA-DPB1, HLA-DRB4, HLA-DRB5, CD74 |
GO:0050896 | 3.6E-06 | 8.20 | 4.13 | 14 | 2454 | Response to stimulus | HLA-DMA, HLA-DPB1, HLA-DRB4, HLA-DRB5, IGHA1, IGLL1, IDO1, CXCL9, ORM1, CCL18, CXCL11, BNIP3, CD86, CD74 |
GO:0002828 | 4.0E-05 | 327.34 | 0.01 | 2 | 6 | Regulation of T-helper 2 type immune response | IDO1, CD86 |
GO:0002682 | 6.7E-05 | 14.53 | 0.45 | 5 | 267 | Regulation of immune system process | HLA-DMA, IDO1, ORM1, CD86, CD74 |
GO:0042092 | 1.2E-04 | 163.62 | 0.02 | 2 | 10 | T-helper 2 type immune response | IDO1, CD86 |
GO:0006954 | 1.4E-04 | 12.44 | 0.52 | 5 | 310 | Inflammatory response | IDO1, CXCL9, ORM1, CCL18, CXCL11 |
GO:0030217 | 1.5E-04 | 34.98 | 0.10 | 3 | 62 | T cell differentiation | HLA-DMA, CD86, CD74 |
GO:0045058 | 1.8E-04 | 130.87 | 0.02 | 2 | 12 | T cell selection | HLA-DMA, CD74 |
GO:0006952 | 2.2E-04 | 8.75 | 0.93 | 6 | 550 | Defense response | IDO1, CXCL9, ORM1, CCL18, CXCL11, BNIP3 |
GO:0045582 | 3.2E-04 | 93.45 | 0.03 | 2 | 16 | Positive regulation of T cell differentiation | HLA-DMA, CD86 |
GO:0045621 | 4.1E-04 | 81.76 | 0.03 | 2 | 18 | Positive regulation of lymphocyte differentiation | HLA-DMA, CD86 |
GO:0002460 | 4.7E-04 | 23.13 | 0.16 | 3 | 92 | Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | HLA-DMA, IDO1, CD86 |
GO:0030098 | 4.7E-04 | 23.13 | 0.16 | 3 | 92 | Lymphocyte differentiation | HLA-DMA, CD86, CD74 |
GO:0002250 | 4.9E-04 | 22.88 | 0.16 | 3 | 93 | Adaptive immune response | HLA-DMA, IDO1, CD86 |
GO:0044419 | 5.8E-04 | 12.38 | 0.40 | 4 | 236 | Interspecies interaction between organisms | HLA-DRB4, MMP1, BNIP3, CD86 |
GO:0009611 | 7.2E-04 | 8.52 | 0.75 | 5 | 445 | Response to wounding | IDO1, CXCL9, ORM1, CCL18, CXCL11 |
GO:0002694 | 8.8E-04 | 18.52 | 0.19 | 3 | 114 | Regulation of leukocyte activation | HLA-DMA, CD86, CD74 |
GO:0050865 | 1.0E-03 | 17.56 | 0.20 | 3 | 120 | Regulation of cell activation | HLA-DMA, CD86, CD74 |
GO:0045580 | 1.1E-03 | 46.67 | 0.05 | 2 | 30 | Regulation of T cell differentiation | HLA-DMA, CD86 |
GO:0051704 | 1.2E-03 | 7.57 | 0.84 | 5 | 498 | Multi-organism process | HLA-DRB4, IDO1, MMP1, BNIP3, CD86 |
GO:0042110 | 1.4E-03 | 15.54 | 0.23 | 3 | 135 | T cell activation | HLA-DMA, CD86, CD74 |
GO:0050776 | 1.7E-03 | 14.54 | 0.24 | 3 | 144 | Regulation of immune response | HLA-DMA, IDO1, CD86 |
GO:0002822 | 1.8E-03 | 36.28 | 0.06 | 2 | 38 | Regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | IDO1, CD86 |
GO:0045619 | 1.8E-03 | 36.28 | 0.06 | 2 | 38 | Regulation of lymphocyte differentiation | HLA-DMA, CD86 |
GO:0002819 | 1.9E-03 | 35.29 | 0.07 | 2 | 39 | Regulation of adaptive immune response | IDO1, CD86 |
GO:0002521 | 1.9E-03 | 13.94 | 0.25 | 3 | 150 | Leukocyte differentiation | HLA-DMA, CD86, CD74 |
GO:0002684 | 1.9E-03 | 13.94 | 0.25 | 3 | 150 | Positive regulation of immune system process | HLA-DMA, IDO1, CD86 |
GO:0006935 | 2.1E-03 | 13.57 | 0.26 | 3 | 154 | Chemotaxis | CXCL9, CCL18, CXCL11 |
GO:0042330 | 2.1E-03 | 13.57 | 0.26 | 3 | 154 | Taxis | CXCL9, CCL18, CXCL11 |
GO:0007267 | 2.3E-03 | 6.50 | 0.97 | 5 | 576 | Cell-cell signaling | CXCL9, PCSK1, CCL18, CXCL11, CD86 |
GO:0050870 | 3.5E-03 | 25.58 | 0.09 | 2 | 53 | Positive regulation of T cell activation | HLA-DMA, CD86 |
GO:0046649 | 4.2E-03 | 10.52 | 0.33 | 3 | 197 | Lymphocyte activation | HLA-DMA, CD86, CD74 |
GO:0051251 | 5.0E-03 | 21.37 | 0.11 | 2 | 63 | Positive regulation of lymphocyte activation | HLA-DMA, CD86 |
GO:0007626 | 5.5E-03 | 9.52 | 0.37 | 3 | 217 | Locomotory behavior | CXCL9, CCL18, CXCL11 |
GO:0009605 | 5.6E-03 | 5.20 | 1.20 | 5 | 710 | Response to external stimulus | IDO1, CXCL9, ORM1, CCL18, CXCL11 |
GO:0030097 | 5.6E-03 | 9.43 | 0.37 | 3 | 219 | Hemopoiesis | HLA-DMA, CD86, CD74 |
GO:0002696 | 6.3E-03 | 18.88 | 0.12 | 2 | 71 | Positive regulation of leukocyte activation | HLA-DMA, CD86 |
GO:0050867 | 6.6E-03 | 18.34 | 0.12 | 2 | 73 | Positive regulation of cell activation | HLA-DMA, CD86 |
GO:0045321 | 6.8E-03 | 8.77 | 0.40 | 3 | 235 | Leukocyte activation | HLA-DMA, CD86, CD74 |
GO:0048534 | 7.1E-03 | 8.66 | 0.40 | 3 | 238 | Hemopoietic or lymphoid organ development | HLA-DMA, CD86, CD74 |
GO:0048583 | 7.2E-03 | 8.62 | 0.40 | 3 | 239 | Regulation of response to stimulus | HLA-DMA, IDO1, CD86 |
GO:0050863 | 8.1E-03 | 16.47 | 0.14 | 2 | 81 | Regulation of T cell activation | HLA-DMA, CD86 |
GO:0002520 | 8.4E-03 | 8.13 | 0.43 | 3 | 253 | Immune system development | HLA-DMA, CD86, CD74 |