Table 4 Univariate and multivariate Cox regression analysis of disease specific survival as function of molecular markers
Univariate analysis | Multivariate analysis including EDNRA | Multivariate analysis including GEM | ||
|---|---|---|---|---|
Nr. of patients | 368 | |||
Median Follow-up months (range) | 62 (2–96) | |||
Age median (range) | 64 (39–79) | HR = 1.01 (P=0.47) | ||
Sex | HR = 1.56 (P=0.007) | HR = 1.62 (P=0.015) | HR = 1.45 (P=0.048) | |
Men | 268 | |||
Women | 100 | |||
T-stage | HR = 1.59 (P<0.001) | HR = 1.28 (P=0.049) | HR = 1.22 (P=0.070) | |
T1 | 43 (12%) | |||
T2 | 129 (35%) | |||
T3 | 146 (40%) | |||
T4 | 50 (13%) | |||
Lymph node metastases | HR = 3.98 (P<0.001) | HR = 3.82 (P<0.001) | HR = 3.55 (P<0.001) | |
N0 | 278 (76%) | |||
N1-3 | 89 (24%) | |||
Grade | HR = 1.18 (P=0.78) | |||
Low grade | 8 (2%) | |||
High grade | 360 (98%) | |||
EDNRA | HR = 1.60 (P=0.046) | HR = 1.63 (P=0.042) | ||
High | 206 (76%) | |||
Low | 65 (24%) | |||
GEM | HR = 1.46 (P=0.032) | HR = 1.33 (P=0.11) | ||
High | 173 (59%) | |||
Low | 120 (41%) |