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Table 4 Cox proportional hazard regression model showing the adjusted hazard ratio on the risk of developing malignancy in different groups of JIA patients by treatment and non-JIA patients

From: Population-based cohort study on the risk of malignancy in East Asian children with Juvenile idiopathic arthritis

 

MTX use, biologics-naive

Anti-TNF biologics-containing

Both MTX- and biologics-naive

Non-JIA

aHR

2.72

6.05

3.14

1

95% CI

0.85 – 8.73

0.82 – 44.61

1.98 – 4.98

-

P-value

0.0932

0.0772

<0.0001

-

  1. aHR: adjusted Hazard Ratio by gender and age; CI: confidence interval; JIA: juvenile idiopathic arthritis; MTX: methotrexate; TNF inhibitor: tumor necrosis factor.