Table 1 Top two classes of genes in signal pathways influenced by 2-24a/Cu in U2os cells

NRF2-mediated oxidative stress response

ABCC2

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

1.688

DNAJA1

DnaJ (Hsp40) homolog, subfamily A, member 1

1.813

DNAJA4

DnaJ (Hsp40) homolog, subfamily A, member 4

4.526

DNAJB1

DnaJ (Hsp40) homolog, subfamily B, member 1

4.619

DNAJB4

DnaJ (Hsp40) homolog, subfamily B, member 4

2.089

DNAJB6

DnaJ (Hsp40) homolog, subfamily B, member 6

1.865

DNAJB9

DnaJ (Hsp40) homolog, subfamily B, member 9

2.260

FOS

FBJ osteosarcoma oncogene

4.602

FOSL1

FOS-like antigen 1

2.550

GCLM

Glutamate-cysteine ligase, modifier subunit

2.936

HERPUD1

Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1

1.767

HMOX1

Heme oxygenase (decycling) 1

6.314

HSPB8

Heat shock 22 kDa protein 8

2.068

JUN

Jun proto-oncogene

1.780

JUNB

Jun-B oncogene

1.982

MAFF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)

3.970

MAFG

v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)

1.878

MAP2K6

Mitogen-activated protein kinase kinase 6

-8.079

PIK3R5

Phosphoinositide-3-kinase, regulatory subunit 5

2.527

SQSTM1

Sequestosome 1

2.395

TXNRD1

Thioredoxin reductase 1

1.527

HIF1α Signaling

EGLN3

egl nine homolog 3 (C. elegans)

1.656

HSP90AA1

Heat shock protein 90 kDa alpha (cytosolic), class A member 1

1.882

JUN

Jun proto-oncogene

1.780

MAPK15

Mitogen-activated protein kinase 15

7.962

MMP1

Matrix metallopeptidase 1 (interstitial collagenase)

3.562

MMP10

Matrix metallopeptidase 10 (stromelysin 2)

6.231

MMP25

Matrix metallopeptidase 25

3.564

PGF

Placental growth factor

3.158

PIK3R5

Phosphoinositide-3-kinase, regulatory subunit 5

2.527

SLC2A1

Solute carrier family 2 (facilitated glucose transporter), member 1

2.141

SLC2A3

Solute carrier family 2 (facilitated glucose transporter), member 3

3.432

VEGFA

Vascular endothelial growth factor A

1.826

VEGFC

Vascular endothelial growth factor C

-1.641