Figure 3
From: Canonical Notch signalling is inactive in urothelial carcinoma
Immunohistochemical staining of NOTCH1 and its ligands DLL1 and JAG1 in representative bladder tumour tissues. (A) NOTCH1, DLL1 and JAG1 staining decreased with tumour invasiveness and became undetectable for NOTCH1 and JAG1 in several muscle invasive bladder tumours. (B) Two examples for intratumoral heterogeneity of DLL1. [1] membrane staining, [2] nuclear staining, [3] no detectable staining.