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Figure 4 | BMC Cancer

Figure 4

From: Differential subcellular and extracellular localisations of proteins required for insulin-like growth factor- and extracellular matrix-induced signalling events in breast cancer progression

Figure 4

Tissue localisation. Differential localisation of SFN (A), Total-AKT1 (B), P-AKT (C), ERK1/2 (D) and P-ERK1/2 (E) is depicted. Nuclear (open circles) and cytoplasmic (closed triangles) immunoreactivity within normal breast (Normal), primary cancer (Primary) and LN metastasis tissues was determined. Antibody immunoreactivity was evaluated semiquantitatively using the Q score (intensity x percentage class, score: 0 – 18) method. Intensity of reactivity (score: 0 = negative; 1 = weak; 2 = moderate, and; 3 = strong). Percentage class (score: 1 = 0-4%; 2 = 5-19%; 3 = 20-39%; 4 = 40-59%; 5 = 60-79%; 6 = 80-100%). Data are displayed using the mean ± 2 standard error (SE). Asterisks (*, ** and ***) indicate statistically significant differences at p < 0.05, <0.01 and <0.001, respectively.

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BMC Cancer

ISSN: 1471-2407

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