Biomarker | n | Median PFS | Median OS | ||||
---|---|---|---|---|---|---|---|
(Alteration) | Mo. | HR (95% CI) | p | Mo. | HR (95% CI) | p | |
p-ERK | 153 | ||||||
pERK low | 55 | 3.1 | 1.01 (0.69-1.47) | 0.98 | 6.2 | 1.29 (0.90-1.83) | 0.16 |
pERK high | 98 | 3.2 | 5.7 | ||||
p-AKT | 35 | ||||||
pAKT low | 21 | 2.5 | 1.04 (0.46-2.34) | 0.92 | 6.4 | 1.03 (0.51-2.11) | 0.93 |
pAKT high | 14 | 3.9 | 6.8 | ||||
p53 | 50 | ||||||
Loss | 4 | 1.8 | 8.1 | ||||
Regular | 20 | 6.0 | 0.24 (0.08-0.79) | 7.0 | 1.10 (0.37-3.25) | ||
Overexpression | 26 | 2.5 | 0.47 (0.16-1.40) | 0.03+ | 5.0 | 1.22 (0.42-3.57) | 0.91+ |