Table 4 Toxicity profile * in nine eligible patients who received a total of 51 cycles
Grade 2 | Grade 3 | Grade 4 | Grade 3/4 | ||||
|---|---|---|---|---|---|---|---|
No. of events (%) | No. of patients (%) | No. of events (%) | No. of patients (%) | No. of events (%) | No. of patients (%) | No. of patients (%) | |
Hematologic | |||||||
Anemia | 27 (53) | 6 (67) | 12 (24) | 7 (78) | 5 (10) | 2 (22) | 7 (78) |
Thrombocytopenia | 5 (10) | 4 (44) | 7 (14) | 3 (33) | 4 (8) | 3 (33) | 6 (67) |
Leucopenia | - | - | 2 (4) | 1 (11) | 49 (96) | 8 (89) | 9 (100) |
Neutropenia | - | - | - | - | 51 (100) | 9 (100) | 9 (100) |
Neutropenic fever | - | - | 6 (12) | 5 (56) | - | - | 5 (56) |
Eye infection | - | - | 1 (2) | 1 (11) | - | - | 1 (11) |
Nail infection | 1 (2) | 1 (11) | - | - | - | - | - |
Anorectal infection | - | - | 1 (2) | 1 (11) | - | - | 1 (11) |
Non-hematologic | |||||||
Headache | 1 (2) | 1 (11) | - | ||||
Dysgeusia | 1 (2) | 1 (11) | - | - | - | - | - |
Oral mucositis | 5 (10) | 4 (44) | 2 (4) | 1 (11) | - | - | 1 (11) |
Nausea | 4 (8) | 2 (22) | - | - | - | - | - |
Vomiting | 9 (18) | 6 (67) | - | - | - | - | - |
Abdominal pain | 6 (12) | 3 (33) | - | - | - | - | - |
Diarrhea | 17 (33) | 5 (56) | 2 (4) | 2 (22) | - | - | 2 (22) |
Chest discomfort | 1 (2) | 1 (11) | - | - | - | - | - |
Pleural effusion | 3 (6) | 2 (22) | - | - | - | - | - |
Pericardial effusion | 1 (2) | 1 (11) | - | - | - | - | - |
Edema | 1 (2) | 1 (11) | - | - | - | - | - |
Peripheral neuropathy | 6 (12) | 2 (22) | 9 (18) | 1 (11) | - | - | 1 (11) |
Tremor | 1 (2) | 1 (11) | - | - | - | - | - |
Muscle weakness | 1 (2) | 1 (11) | 14 (27) | 1 (11) | - | - | 1 (11) |