Clinical Phase I/II trial to Investigate Preoperative Dose-Escalated Intensity-Modulated Radiation Therapy (IMRT) and Intraoperative Radiation Therapy (IORT) in patients with retroperitoneal soft tissue sarcoma: interim analysis

Table 7 Series with preoperative radiation therapy

Author	Year	Type	n	f/u	Pre RT	GTR	Boost	5-year-LC	5-year-OS
Pawlik¹	2006	Pro.,comb.	72	40	89%	79%	44%	60%*	61%*
Gronchi²⁴	2014	Pro.	83	58	88%	95%	17%	63%	59%
Smith²⁵	2014	Pro.,subgr.	40	106	100%	100%	48%	63% (cr)	70%
Tzeng²⁶	2006	Pro.	16	28	100%	88%	0% (d)	80% (2 yr)	n.s.
McBride²⁷	2013	Retro.	33	33	100%	100%	30%	63% (3 yr)	64% (3 yr)
Sweeting²⁸	2013	Retro.	18	43	94%	100%	100%	64%	72%
Alford²⁹	2012	Retro.	24	28	100%	75%	0%	68%	54%
Present data	2014	Pro.,interim	27	33	93%	96%	85%	72%	74%

pro.: prospective trial, comb., combined analysis, subgr.: subgroup analysis, interim: interims analysis, n: number of patients, f/u: median follow-up in months, pre RT: percentage of patients with completion of preoperative radiation therapy as planned, GTR: percentage of patients in whom gross total resection was achieved, boost: percentage of patients who received an additional boost via IORT or Brachytherapy, d: preoperative radiation therapy was dose escalated, LC: local control, OS: Overall survival, *: in grossly resected patients, cr: crude rate, 2 yr: 2-year rate, 3 yr: 3-year rate.

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