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Table 7 Series with preoperative radiation therapy

From: Clinical Phase I/II trial to Investigate Preoperative Dose-Escalated Intensity-Modulated Radiation Therapy (IMRT) and Intraoperative Radiation Therapy (IORT) in patients with retroperitoneal soft tissue sarcoma: interim analysis

Author Year Type n f/u Pre RT GTR Boost 5-year-LC 5-year-OS
Pawlik1 2006 Pro.,comb. 72 40 89% 79% 44% 60%* 61%*
Gronchi24 2014 Pro. 83 58 88% 95% 17% 63% 59%
Smith25 2014 Pro.,subgr. 40 106 100% 100% 48% 63% (cr) 70%
Tzeng26 2006 Pro. 16 28 100% 88% 0% (d) 80% (2 yr) n.s.
McBride27 2013 Retro. 33 33 100% 100% 30% 63% (3 yr) 64% (3 yr)
Sweeting28 2013 Retro. 18 43 94% 100% 100% 64% 72%
Alford29 2012 Retro. 24 28 100% 75% 0% 68% 54%
Present data 2014 Pro.,interim 27 33 93% 96% 85% 72% 74%
  1. pro.: prospective trial, comb., combined analysis, subgr.: subgroup analysis, interim: interims analysis, n: number of patients, f/u: median follow-up in months, pre RT: percentage of patients with completion of preoperative radiation therapy as planned, GTR: percentage of patients in whom gross total resection was achieved, boost: percentage of patients who received an additional boost via IORT or Brachytherapy, d: preoperative radiation therapy was dose escalated, LC: local control, OS: Overall survival, *: in grossly resected patients, cr: crude rate, 2 yr: 2-year rate, 3 yr: 3-year rate.
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