Author
|
Year
|
Type
|
n
|
f/u
|
Pre RT
|
GTR
|
Boost
|
5-year-LC
|
5-year-OS
|
---|
Pawlik1
|
2006
|
Pro.,comb.
|
72
|
40
|
89%
|
79%
|
44%
|
60%*
|
61%*
|
Gronchi24
|
2014
|
Pro.
|
83
|
58
|
88%
|
95%
|
17%
|
63%
|
59%
|
Smith25
|
2014
|
Pro.,subgr.
|
40
|
106
|
100%
|
100%
|
48%
|
63% (cr)
|
70%
|
Tzeng26
|
2006
|
Pro.
|
16
|
28
|
100%
|
88%
|
0% (d)
|
80% (2 yr)
|
n.s.
|
McBride27
|
2013
|
Retro.
|
33
|
33
|
100%
|
100%
|
30%
|
63% (3 yr)
|
64% (3 yr)
|
Sweeting28
|
2013
|
Retro.
|
18
|
43
|
94%
|
100%
|
100%
|
64%
|
72%
|
Alford29
|
2012
|
Retro.
|
24
|
28
|
100%
|
75%
|
0%
|
68%
|
54%
|
Present data
|
2014
|
Pro.,interim
|
27
|
33
|
93%
|
96%
|
85%
|
72%
|
74%
|
- pro.: prospective trial, comb., combined analysis, subgr.: subgroup analysis, interim: interims analysis, n: number of patients, f/u: median follow-up in months, pre RT: percentage of patients with completion of preoperative radiation therapy as planned, GTR: percentage of patients in whom gross total resection was achieved, boost: percentage of patients who received an additional boost via IORT or Brachytherapy, d: preoperative radiation therapy was dose escalated, LC: local control, OS: Overall survival, *: in grossly resected patients, cr: crude rate, 2 yr: 2-year rate, 3 yr: 3-year rate.