|
Toxicity
|
All grades
|
Grade 1
|
Grade 2
|
Grade 3
|
|---|
|
GI
| | | | |
|
Diarrhea
|
11
|
5
|
4
|
2
|
|
Nausea
|
11
|
6
|
5
|
0
|
|
Appetite loss
|
4
|
3
|
1
|
0
|
|
Bloating
|
8
|
3
|
5
|
0
|
|
Reflux
|
3
|
2
|
1
|
0
|
|
Constipation
|
3
|
1
|
2
|
0
|
|
Hematological
| | | | |
|
Anemia
|
18
|
12
|
5
|
1
|
|
Leucopenia
|
9
|
5
|
3
|
1
|
|
Thrombopenia
|
8
|
8
|
0
|
0
|
|
Skin
| | | | |
|
Erythema
|
10
|
10
|
0
|
0
|
|
GU
| | | | |
|
Frequency/urgency
|
3
|
1
|
2
|
0
|
|
Dysuria
|
4
|
3
|
1
|
0
|
|
Bladder obstruction
|
1
|
0
|
1
|
0
|
|
Ureter obstruction
|
1
|
0
|
0
|
1
|
|
Infection
|
2
|
0
|
1
|
1
|
|
Other
| | | | |
|
Pain
|
6
|
6
|
0
|
0
|
|
Fatigue
|
2
|
1
|
1
|
0
|
|
Motor neuropathy*
|
1
|
0
|
1
|
0
|
|
Varicocele
|
1
|
0
|
1
|
0
|
|
Hypokalemia
|
1
|
1
|
1
|
1
|
- GI: gastrointestinal, GU: genitourinary, *:transient.
