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Table 3 Treatment characteristics

From: Clinical Phase I/II trial to Investigate Preoperative Dose-Escalated Intensity-Modulated Radiation Therapy (IMRT) and Intraoperative Radiation Therapy (IORT) in patients with retroperitoneal soft tissue sarcoma: interim analysis

Treatment n %   n %
Neoadjuvant IMRT    Surgery   
Completed 25 93 Gross total 26 96
Not completed 2 7 Explo. lap 1 4
GTV volume [ccm]    Resection margin   
Median 1146 R0 6 22
Min 62 R1 20 74
Max 6763 Explo. Lap. 1 4
PTV volume [ccm]    Cont. organ resection   
Median 2452 yes 26 96
Min 388 no 1 4
Max 8516    
    Number of organs*   
GTV dose [Gy]    0 (explo Lap) 1 4
Median 50 1 7 26
Min 26 2 8 30
Max 55 3 5 19
    4 6 22
PTV dose [Gy]      
Median 45 Type of organ   
Min 23,4 Nephrectomy 18 67
Max 50 Hemicolectomy 16 59
    Splenectomy 8 30
Number of beams    Partial pancreatectomy 8 30
Median 9 Cholecystectomy 8 30
Min 5 Small bowel resection 3 11
Max 14 Rectum resection 3 11
    Partial colpectomy 2 7
Number of segments    Partial liver resection 1 4
Median 144 Cystectomy 1 4
Min 43 Adnexectomy 1 4
Max 242 Hysterectomy 1 4
IOERT    Muscle resection   
Completed 23 Yes 9 33
Not completed 4 No 18 67
    Psoas 4 15
IOERT dose [Gy]    Diaphragm 6 22
Median 12    
Min 10 Vessel resection   
Max 20 Yes 8 30
    No 19 70
IOERT energy [MeV]    Major artery 4 15
Median 8 Major vein 7 26
Min 6    
Max 12 Nerve resection   
    Yes 2 7
IOERT cone size [cm]    No 25 93
Median 8    
Min 5    
Max 18 *: Cholecystectomy excluded  
  1. n:number of patients, %: percentage, IMRT: intensity-modulated radiation therapy, GTV: gross tumor volume, PTV: planning target volume, ccm : cubic centimetre, Gy: gray, IOERT : intraoperative electron radiation therapy, MeV : mega electron volts, cm : centimetre, explo. Lap. : explorative laparotomy, R0: microscopically negative, R1 : microscopically positive, cont. contiguous.
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