Clinical Phase I/II trial to Investigate Preoperative Dose-Escalated Intensity-Modulated Radiation Therapy (IMRT) and Intraoperative Radiation Therapy (IORT) in patients with retroperitoneal soft tissue sarcoma: interim analysis

Table 3 Treatment characteristics

Treatment	n	%		n	%
Neoadjuvant IMRT			Surgery
Completed	25	93	Gross total	26	96
Not completed	2	7	Explo. lap	1	4
GTV volume [ccm]			Resection margin
Median	1146		R0	6	22
Min	62		R1	20	74
Max	6763		Explo. Lap.	1	4
PTV volume [ccm]			Cont. organ resection
Median	2452		yes	26	96
Min	388		no	1	4
Max	8516
			Number of organs*
GTV dose [Gy]			0 (explo Lap)	1	4
Median	50		1	7	26
Min	26		2	8	30
Max	55		3	5	19
			4	6	22
PTV dose [Gy]
Median	45		Type of organ
Min	23,4		Nephrectomy	18	67
Max	50		Hemicolectomy	16	59
			Splenectomy	8	30
Number of beams			Partial pancreatectomy	8	30
Median	9		Cholecystectomy	8	30
Min	5		Small bowel resection	3	11
Max	14		Rectum resection	3	11
			Partial colpectomy	2	7
Number of segments			Partial liver resection	1	4
Median	144		Cystectomy	1	4
Min	43		Adnexectomy	1	4
Max	242		Hysterectomy	1	4
IOERT			Muscle resection
Completed	23		Yes	9	33
Not completed	4		No	18	67
			Psoas	4	15
IOERT dose [Gy]			Diaphragm	6	22
Median	12
Min	10		Vessel resection
Max	20		Yes	8	30
			No	19	70
IOERT energy [MeV]			Major artery	4	15
Median	8		Major vein	7	26
Min	6
Max	12		Nerve resection
			Yes	2	7
IOERT cone size [cm]			No	25	93
Median	8
Min	5
Max	18		*: Cholecystectomy excluded

n:number of patients, %: percentage, IMRT: intensity-modulated radiation therapy, GTV: gross tumor volume, PTV: planning target volume, ccm : cubic centimetre, Gy: gray, IOERT : intraoperative electron radiation therapy, MeV : mega electron volts, cm : centimetre, explo. Lap. : explorative laparotomy, R0: microscopically negative, R1 : microscopically positive, cont. contiguous.