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Table 1 Inhibitory concentration (IC 50 ) of Antp-TPR or the combination of Antp-TPR and R11-Hsp70

From: Synergetic cytotoxic activity toward breast cancer cells enhanced by the combination of Antp-TPR hybrid peptide targeting Hsp90 and Hsp70-targeted peptide

  

IC50(μM)*

 
 

Antp-TPR

Antp-TPR + R11-Hsp70**

Ratio (Antp-TPR / Antp-TPR + R11-Hsp70

MDA-MD-231

31.2 ± 3.0

16.1 ± 1.0

1.9

BT20

26.1 ± 3.0

8.5 ± 1.0

3.1

BT474

34.1 ± 2.7

23.6 ± 1.1

1.4

MDA-MD-361

33.8 ± 2.6

23.1 ± 2.2

1.5

  1. *Results are the mean of three independent observations each performed in triplicate.
  2. **IC50 of Antp-TPR in the presence of R11-Hsp70 (10 μM).
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BMC Cancer

ISSN: 1471-2407

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