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Figure 3 | BMC Cancer

Figure 3

From: Synergetic cytotoxic activity toward breast cancer cells enhanced by the combination of Antp-TPR hybrid peptide targeting Hsp90 and Hsp70-targeted peptide

Figure 3

Decrease of Hsp90 client proteins after treatment with Antp-TPR in the presence of R11-Hsp70 in BT20 and MDA-MB-231 cells. (A) BT20 and MDA-MB-231 cells were treated with or without Antp-TPR (20 μM), R11-Hsp70 (10 μM), or a combination of these peptides for 18 h and examined by western blotting for the expression of Hsp90, Hsp70, Hsp27, Hop, Akt, p53, cRaf, and β-actin using corresponding antibodies. β-Actin was used as the loading control. Bands were visualized by chemiluminescence. (B) Densitometric analysis of Hsp90 client proteins (Akt, P53, and c-Raf) was performed using Multi Gauge software as described in the Materials and Methods section.

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BMC Cancer

ISSN: 1471-2407

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