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Figure 4 | BMC Cancer

Figure 4

From: Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model

Figure 4

VT improves IR-induced acute wound healing. (A) Anti-CD45 (leukocytes, top) and anti-CD31 (endothelial cells, bottom)-stained 200x magnified sections (brown colour) in irradiated PBS and VT-treated animals 14 days after 40 Gy insult. Scale bars = 62.5 μm. Quantified brown pixel to total pixel area (outlined by yellow hatched line) ratios graphed on the right. Expressed as mean ± SD of 3 mice per group. (B) H&E-stained histological sections of representative 40 Gy-irradiated and PBS/VT-treated mouse skin 28 days after irradiation. Scale bars = 1 mm. (C) Healed 40 Gy-irradiated skin blood parameters (oxyHb, StO2, total Hb, mean ± SD) 28 days after IR, normalized to PBS-treated non-irradiated values. (D) Profibrogenic cytokine TGF-β levels in blood serum harvested 28 days after 40 Gy irradiation or no irradiation of PBS/VT-treated animals, expressed as mean ± SEM. ** signifies P < 0.01, and “ns” denotes ‘not significant’.

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