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Table 1 Correlations between EGFR mutations and clinicopathological features

From: Clinicopathological features and EGFR gene mutation status in elderly patients with resected non–small-cell lung cancer

Characteristics Total No. of patients
   EGFRstatus p a KRASstatus p a
   Mutation Wild-type   Mutation Wild-type  
  (n = 388) (n = 185, 47.7%) (n = 203, 52.3%)   (n = 33, 8.5%) (n = 355, 91.5%)  
Mean age, yr ± SDb 66.6 ± 10.0 65.1 ± 10.3 67.9 ± 9.57 0.462 68.6 ± 9.11 66.4 ± 10.1 0.553
Gender     <0.001    0.552
Male 228 75 153   21 207  
Female 160 110 50   12 148  
Histological type     <0.001    0.059
Adenocarcinoma 302 183 119   30 272  
Others 86 2 84   3 83  
Vascular invasion        
Ly - 314 155 159 0.172 25 289 0.429
Ly + 74 30 44   8 66  
V - 261 151 110 <0.001 23 238 0.756
V + 127 34 93   10 117  
p-stage     <0.001    
I 293 155 138   22 271 0.217
II / III 95 30 65   11 84  
T-factor     <0.001    
T1 197 114 83   14 183 0.316
T2 / 3 191 71 120   19 191  
Tumor diameter (cm) 3.03 ± 1.43 2.68 ± 0.92 3.35 ± 1.71 <0.001 3.46 ± 1.99 2.99 ± 1.36 0.001
N-factor     0.348    
N0 322 157 165   29 293 0.435
N1 / 2 66 28 38   4 62  
Smoking status     <0.001    0.107
Non-smoker 157 106 51   9 148  
Smoker 231 79 152   24 207  
Pre-existing cardiopulmonary comorbidity 203 86 117 0.028 20 183 0.319
  1. ap < 0.05 statistically significant.
  2. bSD, standard deviation.
  3. EGFR, epidermal growth factor receptor; KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; ND, lymph node dissection.