Table 6 Correlation between phosphorylated STAT3 and ERK1 IHC expression to poor response to chemotherapy for a percentage of viable residual cells lower than 5%
IHC score | Good responders | Poor responders | p-value | |
|---|---|---|---|---|
Phosphorylated STAT3 | 0 or 1 | 13 | 12 | 0.013 |
2 or 3 | 3 | 17 | ||
VPP(PR) = 17/20 = 85%/VPN(GR) = 13/25 = 52% | ||||
Phosphorylated ERK1 | 0 or 1 | 13 | 12 | 0.035 |
2 or 3 | 4 | 16 | ||
VPP(PR) = 16/20 = 80%/VPN(GR) = 13/25 = 52% | ||||
Phosphorylated STAT3 and ERK1 | Both 0-1 | 11 | 5 | 0.007 |
Intermediate | 5 | 10 | ||
Both 2-3 | 1 | 10 | ||
VPP(both/PR) = 10/11 = 91%/VPN(both/GR) = 11/16 = 69% | ||||