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Table 5 Correlation between phosphorylated STAT3 and ERK1 IHC expression to poor response to chemotherapy for a percentage of viable residual cells ≤10%

From: Correlation between ERK1 and STAT3 expression and chemoresistance in patients with conventional osteosarcoma

 

IHC score

Good responders

Poor responders

p-value

Phosphorylated STAT3

0 or 1

16

9

0.036

2 or 3

6

14

VPP(PR) = 14/20 = 70%/VPN(GR) = 16/25 = 64%

Phosphorylated ERK1

0 or 1

17

8

0.007

2 or 3

5

15

VPP(PR) = 15/20 = 75%/VPN(GR) = 17/25 = 68%

Phosphorylated STAT3 and ERK1

Both 0-1

12

4

0.003

Intermediate

8

7

Both 2-3

1

10

VPP(both/PR) = 10/11 = 91%/VPN(both/GR) = 12/16 = 75%