High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients

Table 3 Correlation between combined expression level of LSD1, HDAC2 and SIRT1 and ki-67 expression

N = 423	3× low	1× high	2× high	3× high	total
Ki-67
No expression	81 (67.5%)	40 (44.0%)	67 (51.1%)	37 (45.7%)	225 (53.2%)
Expression	39 (32.5%)	51 (56.0%)	64 (48.9%)	44 (54.3%)	198 (46.8%)
Total	120	91	131	81	423
Chi-square: p = 0.002

Ki-67 expression versus the combined expression levels of LSD1, HDAC2 and SIRT1 in 423 breast cancer patients are shown. Patients were divided into four categories based on the expression levels of the histone-modifying enzymes: all enzymes below median (3x low), one enzyme above median (1× high), two enzymes above median (2× high) and all three enzymes above median (3× high).

ISSN: 1471-2407