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Figure 4 | BMC Cancer

Figure 4

From: High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients

Figure 4

Overall and relapse-free survival analyses of the expression levels LSD1, HDAC2 and SIRT1. Cumulative incidence curves of the univariate relapse-free survival (RFS) analysis of LSD1 (A), HDAC2 (B), and SIRT1 (C) in breast tumors (n = 460). ‘Low expression’ was defined as expression level below median or equal to median and ‘high expression’ was defined as expression level above median. (D) Hazard ratios (HR), their 95% confidence intervals (95% CI) and their corresponding p-values for LSD1, HDAC2, and SIRT1 expression for overall survival (OS) and RFS were evaluated with the Cox proportional hazard model for uni- and multivariate analysis. Significant p-values (≤0.05) are indicated in bold.

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