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Figure 1 | BMC Cancer

Figure 1

From: High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients

Figure 1

LSD1, HDAC2 and SIRT1 expression in breast cancer. Expression levels of LSD1, HDAC2 and SIRT1 were immunohistochemically determined in breast tumors as percentage of tumor cells with positive nuclear staining. The respective cut-off values, based on the median expression level, for low and high expression were 85% for LSD1, 80% for HDAC2 and 70% for SIRT1. For each staining a representative normal tissue core (left), a tumor tissue core with expression above median (middle) and below median (right) is shown. Pictures of the 0.6 mm tumor tissue cores were taken with a 100× magnification and a zoomed-in section of the tumor tissue cores is shown on the right of each image (400× magnification). The brown color represents the expression level of the enzymes.

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