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Table 4 Family and personal history of hiatal hernia and risk of esophageal and gastric adenocarcinoma

From: Family history of cancer and gastroesophageal disorders and risk of esophageal and gastric adenocarcinomas: a case–control study

Personal history of hiatal hernia

Family history of hiatal hernia

 

EA

GCA

DGA

Controls

Cases

OR (95% CI)a

P a

Cases

OR (95% CI)a

P a

Cases

OR (95% CI)a

P a

No

No

1117

93

1.00 (ref)

 

129

1.00 (ref)

 

249

1.00 (ref)

 

No

Yes

68

6

1.26 (0.52-3.08)

0.61

13

1.89 (0.99-3.61)

0.056

8

0.89 (0.40-1.97)

0.77

Yes

No

82

36

4.91 (3.04-7.93)

<0.001

23

2.36 (1.40-3.97)

0.001

17

1.44 (0.80-2.60)

0.22

Yes

Yes

12

10

10.75 (4.26-27.12)

<0.001

9

6.55 (2.60-16.50)

<0.001

2

-

-

    

P for interaction=

0.50

  

0.48

  

0.99

  1. Abbreviations: EA, esophageal adenocarcinoma; GCA, gastric cardiac adenocarcinoma; DGA, distal gastric adenocarcinoma; OR, odds ratio; CI, confidence interval.
  2. aResults were estimated from multivariate polytomous logistic regression, with adjustment for age, sex, race, education, birth place, cigarette smoking status, body mass index and history of diabetes.