Skip to main content

Advertisement

Table 4 Family and personal history of hiatal hernia and risk of esophageal and gastric adenocarcinoma

From: Family history of cancer and gastroesophageal disorders and risk of esophageal and gastric adenocarcinomas: a case–control study

Personal history of hiatal hernia Family history of hiatal hernia   EA GCA DGA
Controls Cases OR (95% CI)a P a Cases OR (95% CI)a P a Cases OR (95% CI)a P a
No No 1117 93 1.00 (ref)   129 1.00 (ref)   249 1.00 (ref)  
No Yes 68 6 1.26 (0.52-3.08) 0.61 13 1.89 (0.99-3.61) 0.056 8 0.89 (0.40-1.97) 0.77
Yes No 82 36 4.91 (3.04-7.93) <0.001 23 2.36 (1.40-3.97) 0.001 17 1.44 (0.80-2.60) 0.22
Yes Yes 12 10 10.75 (4.26-27.12) <0.001 9 6.55 (2.60-16.50) <0.001 2 - -
     P for interaction= 0.50    0.48    0.99
  1. Abbreviations: EA, esophageal adenocarcinoma; GCA, gastric cardiac adenocarcinoma; DGA, distal gastric adenocarcinoma; OR, odds ratio; CI, confidence interval.
  2. aResults were estimated from multivariate polytomous logistic regression, with adjustment for age, sex, race, education, birth place, cigarette smoking status, body mass index and history of diabetes.