Figure 1

The Ras status of yeast cells modulates the toxicity of HQ. The Area Under Curve (AUC) was calculated for each strain after 24 h of exposure to the indicated doses of HQ. The bars represent mean AUC as a percentage of the untreated for each strain with standard error of three replicates. Sensitivity was determined by comparison to the wild type strain (gray bars = wild type; white bars = indicated deletion/overexpression strain). A ira2Δ (increased Ras signaling) is sensitive to HQ. B ras1Δ (reduced Ras signaling) is resistant to HQ. C ras2Δ showed a response to HQ equivalent to WT. D Overexpression of RAS1 (increased Ras signaling) results in sensitivity to HQ.