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Figure 7 | BMC Cancer

Figure 7

From: Variable NF-κB pathway responses in colon cancer cells treated with chemotherapeutic drugs

Figure 7

Changes in CXCR1 and CXCR2 expression induced by CPT treatment. A: Negligible basal expression of CXCR1 and CXCR2 in HCT116 and SW620 cells (Cell Miner [36]). B: Relative fold change in CXCR1 mRNA in SW480 cells treated with CPT, SM7368, or a combination of the two. C-D: Relative fold changes in mRNAs for CXCR1 and CXCR2 in HCT116 cells treated with vehicle (ctrl), CPT (0.05 μM), SM7368 (10 μM), or a combination of the two. CPT induced a marked increase in CXCR2 expression in HCT116 cells, and the expression was inhibited by treatment of the cells with SM7368, an NF-κB inhibitor.

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