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Table 3 Joint analyses of the melanoma risk indicator ’not being vaccinated with either BCG or vaccinia’ and four co-variables of melanoma risk a

From: The biography of the immune system and the control of cancer: from St Peregrine to contemporary vaccination strategies

Co-variable

Vaccination

Concomitant effect (type of)

 

Yes

No

 

Skin-type (Fitzpatrick)

   

III/IV

1.00 n = 607

1.68 (0.93-3.05) n = 58

 

II

1.80 (1.18-2.78) n = 396

2.15 (0.65-8.34) n = 30

 

I

1.54 (1.16-2.05) n = 126

6.37 (3.50-19.64) n = 12

Synergistic

Sunburns in life

   

0

1.00 n = 338

1.51 (0.76-3.01) n = 46

 

1-5

0.93 (0.68-1.26) n = 596

2.29 (1.14-4.76) n = 45

 

>5

1.39 (0.91-2.14) n = 191

5.30 (0.87-102.48) n = 8

Synergistic

Naevi

   

0

1.00 n = 272

2.51 (1.16-5.77) n = 35

 

1-4

1.05 (0.70-1.48) n = 387

5.24 (1.89-17.10) n = 22

 

>4

1.56 (1.10-2.22) n = 456

1.71 (0.84-3.57) n = 42

Non-cumulative

Freckles on arm

   

0

1.00 N = 457

3.26 (1.60-6.87) n = 39

 

10-20

1.57 (1.17-2.10) n = 426

2.38 (1.09-5.32) n = 31

 

>20

3.03 (2.13-4.35) n = 247

4.06 (1.78-10.17) n = 30

Non-cumulative

  1. aCompared with ‘vaccinated with BCG and/or vaccinia’. Data expressed as Odds Ratios (95% Confidence Intervals) for melanoma risk, adjusted for centre, sex, age, and other known risk factors. n = number of cases and controls. Summarized from the FEBIM study [83].