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Table 3 Joint analyses of the melanoma risk indicatornot being vaccinated with either BCG or vacciniaand four co-variables of melanoma risk a

From: The biography of the immune system and the control of cancer: from St Peregrine to contemporary vaccination strategies

Co-variable Vaccination Concomitant effect (type of)
  Yes No  
Skin-type (Fitzpatrick)    
III/IV 1.00 n = 607 1.68 (0.93-3.05) n = 58  
II 1.80 (1.18-2.78) n = 396 2.15 (0.65-8.34) n = 30  
I 1.54 (1.16-2.05) n = 126 6.37 (3.50-19.64) n = 12 Synergistic
Sunburns in life    
0 1.00 n = 338 1.51 (0.76-3.01) n = 46  
1-5 0.93 (0.68-1.26) n = 596 2.29 (1.14-4.76) n = 45  
>5 1.39 (0.91-2.14) n = 191 5.30 (0.87-102.48) n = 8 Synergistic
Naevi    
0 1.00 n = 272 2.51 (1.16-5.77) n = 35  
1-4 1.05 (0.70-1.48) n = 387 5.24 (1.89-17.10) n = 22  
>4 1.56 (1.10-2.22) n = 456 1.71 (0.84-3.57) n = 42 Non-cumulative
Freckles on arm    
0 1.00 N = 457 3.26 (1.60-6.87) n = 39  
10-20 1.57 (1.17-2.10) n = 426 2.38 (1.09-5.32) n = 31  
>20 3.03 (2.13-4.35) n = 247 4.06 (1.78-10.17) n = 30 Non-cumulative
  1. aCompared with ‘vaccinated with BCG and/or vaccinia’. Data expressed as Odds Ratios (95% Confidence Intervals) for melanoma risk, adjusted for centre, sex, age, and other known risk factors. n = number of cases and controls. Summarized from the FEBIM study [83].
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