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Figure 4 | BMC Cancer

Figure 4

From: The radiosensitising effect of gemcitabine and its main metabolite dFdU under low oxygen conditions is in vitro not dependent on functional HIF-1 protein

Figure 4

Cell cycle analysis after 24 h treatment with gemcitabine or dFdU under normoxia versus hypoxia. A. Cell cycle distribution of MDA-MB-231 wt cells. Cells were treated with 0, 4 or 8 nM gemcitabine (dFdC) or 2 or 4 μM dFdU for 24 h under normoxia or hypoxia. All results are from at least 3 independent experiments. B. Cell cycle histogram of MDA-MB-231 wt cells after 24 h incubation with 0, 4 or 8 nM gemcitabine (dFdC) or 2 or 4 μM dFdU for 24 h under normoxia (N) or hypoxia (H). FL2-A = DNA content; M1 = G0/1 phase; M2 = S phase; M3 = G2/M phase.

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