Elevated levels of plasma D-dimer predict a worse outcome in patients with nasopharyngeal carcinoma

BMC Cancer

Table 3 Multivariate Cox proportional hazards regression analysis

Characteristic	DFS (n = 717)			DMFS (n = 717)			OS (n = 717)
Characteristic	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Tumour stage (T3-4 vs. T1-2)	1.23	0.76 to 1.99	0.395	1. 36	0.76 to 2.45	0.305	1.04	0.61 to 1.79	0.88
Node stage (N2-3 vs. N0-1)	1.14	0.76 to 1.71	0.516	1.43	0.88 to 2.33	0.148	1.08	0.68 to 1.72	0.756
Chemoradiotherapy (yes vs. no)	1.23	0.55 to 2.74	0.621	0.84	0.40 to 2.02	0.7	0.89	0.36 to 2.18	0.793
IMRT vs. 2DRT/3DCRT	0.62	0.42 to 0.90	0.013	0.76	0.48 to 1.21	0.246	0.99	0.64 to 1.52	0.954
High DNA vs. Low DNA	2.41	1.59 to 3.64	< 0.001	2.77	1.66 to 4.62	< 0.001	3.06	1.87 to 5.02	< 0.001
CRP, mg/L (≥1.61 vs. < 1.61)	1.14	0.78 to 1.68	0.495	1.35	0.85 to 2.14	0.21	1.48	0.95 to 231	0.082
LDH, U/L (≥167 vs. < 167)	1.22	0.84 to 1.77	0.290	1.35	0.86 to 2.11	0.189	1.23	0.81 to 1.86	0.34
D-dimer, ug/L (≥0.8 vs. < 0.8)	1.60	1.08 to 2.37	0.020	1.79	1.13 to 2.82	0.013	1.58	1.02 to 2.45	0.043
Smoking (yes vs. no)	1.26	0.87 to 1.82	0.216	1.58	1.03 to 2.43	0.036	1.35	0.89 to 2.06	0.159

Abbreviations: ECOG Eastern Cooperative Oncology Group, 2DRT two-dimensional radiotherapy, 3DCRT three-dimensional conformal radiotherapy, IMRT intensity-modulated radiotherapy, Low DNA denotes a low EBV DNA level of <4000 copies/ml, High DNA denotes a high EBV DNA level of ≥4000 copies/ml, LDH Serum Lactate Dehydrogenase Levels, CRP high-sensitivity C-reactive protein, DFS disease-free survival, DMFS metastasis-free survival, OS overall survival.

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