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Figure 1 | BMC Cancer

Figure 1

From: Combination of hepatocyte specific delivery and transformation dependent expression of shRNA inducing transcriptional gene silencing of c-Myc promoter in hepatocellular carcinoma cells

Figure 1

HCC specific expression of AFP promoter/enhancer system. (A) Various combinations of AFP promoter/enhancer fusion constructs with downstream luciferase reporter in pGl3-Basic vector. (B and C) 48 hours after transfection, the observed luciferase activity was maximum in the case of AFPEn–Pr + 25 – luc followed by NFκBEn–Pr + 25 – luc and lastly by AFPPr + 25 – luc in both HepG2 and Huh7 cells. (D and E) No luciferase activity was observed through AFP promoter/enhancer systems in untransformed Chang Liver and non-liver CHO cells.

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