Table 4 Survival according to the individual genotypes

a: All patients

MTHFR C677T

CC

254

54.1

0.412

CT

262

82.7

0.88 (0.67-1.15)

TT

53

n.r.

0.75 (0.46-1.22)

CC

254

54.1

0.237

CT + TT

315

82.7

0.86 (0.66-1.11)

MTHFR A1298C

AA

244

82.7

0.036

AC

268

47.1

1.31 (1.0-1.72)

CC

54

74.2

0.77 (0.47-1.28)

AC

268

47.1

0.016

AA + CC

301

82.7

0.73 (0.56-0.94)

n

MS (months)

p

HR (95% CI)

b: Neoadjuvantly treated patients

MTHFR C677T

CC

161

55.4

0.745

CT

179

82.7

0.98 (0.7-1.38)

TT

29

n.r.

0.77 (0.4-1.51)

CC

161

55.4

0.77

CT + TT

208

82.7

0.95 (0.69-1.32)

MTHFR A1298C

AA

156

101.9

0.063

AC

179

47.1

1.43 (1.02-2.01)

CC

31

74.2

0.85 (0.44-1.67)

AC

179

47.1

0.02

AA + CC

190

101.9

0.68 (0.49-0.94)

n

MS (months)

p

HR (95% CI)

c: Primarily resected patients

MTHFR C677T

CC

93

54.1

0.295

CT

83

n.r.

0.72 (0.45-1.15)

TT

24

66.0

0.69 (0.34-1.4)

CC

93

54.1

0.119

CT + TT

107

66.0

MTHFR A1298C

AA

88

66.0

0.366

AC

89

47.6

0.16 (0.74-1.82)

CC

23

62.2

0.68 (0.31-1.46)

AC

89

47.6

0.295

AA + CC

111

66.0

0.79 (0.52-1.22)