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Figure 2 | BMC Cancer

Figure 2

From: CDK11p58inhibits ERα-positive breast cancer invasion by targeting integrin β3 via the repression of ERα signaling

Figure 2

CDK11 p58 inhibits breast cancer cell metastasis in an ERα-dependent manner. (A) ZR-75-30 cells were transfected with wild-type CDK11p58 (p58), kinase activated mutant (T370D), kinase dead mutant (T370A) or control vectors. After 6 h, Transwell assays were performed as described. Crystal violet staining of invading cells is shown. Data are expressed as the mean ± SEM of the number of invading cells in more than five separate areas. *P < 0.05 versus vector controls (n = 3 experiments). (B) MDA-MB-231 cells were transfected with CDK11p58 or various mutants. After 6 h, Transwell assays were performed as described. Crystal violet staining of invading cells is shown. Data are expressed as the mean ± SEM of the number of invading cells in more than five separate areas.

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