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Figure 1 | BMC Cancer

Figure 1

From: Polyploid giant cancer cells with budding and the expression of cyclin E, S-phase kinase-associated protein 2, stathmin associated with the grading and metastasis in serous ovarian tumor

Figure 1

PGCCs with budding daughter cells. A. HEY PGCCs and control HEY cells. a. Control HEY cells (×400). b. HEY PGCCs induced by treatment with 450 μM of CoCl2 for 48 h (small black arrow heads PGCCs; large black arrow heads budded daughter cells from PGCC; ×400). c. PGCCs generated daughter cells via budding (black arrow heads budded daughter cells from PGCC; ×100). d. PGCCs use budding for renewal and fast reproduction. Cells in panel 1A-c were cultured in complete medium for 8 h (×100). B. Western blot of cyclin E and SKP2 expression in HEY PGCCs with budding and control HEY cells. C. ICC staining of stathmin in HEY PGCCs with budding and control HEY cells (×200).

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