Table 4 Sunitinib and SU12662 CL/F and AUC 24,ss estimates for each past GI surgery subgroup
From: Effect of gastrointestinal resection on sunitinib exposure in patients with GIST
Parameter | Past GI surgery subgroup | |||||
|---|---|---|---|---|---|---|
Major gastrectomy (n = 45) | Partial gastrectomy (n = 58 ) | Small bowel resection (n = 118) | Combination of gastrectomy and small bowel resection (n = 8 ) | Colon resection (n = 13) | Controls (n = 63) | |
Number of PK samples per subject, median (range) | 7 (1–32) | 9 (1–38) | 7 (1–35) | 10 (2–35) | 13 (2–30) | 7 (1–37) |
Sunitinib | ||||||
AUC 24,ss (ng*hr/mL) | 1171 (1099–1248) | 1294 (1228–1365) | 1194 (1141–1250) | 931 (676–1283)* | 1325 (1109–1583) | 1177 (1097–1263) |
CL/F (L/hr) | 42.7 (40.1 - 45.5) | 38.6 (36.6 - 40.7) | 41.9 (40.0 - 43.8) | 53.7 ( 39.0 - 74.0)* | 37.7 (31.6 - 45.1) | 42.5 (39.6 - 45.6) |
SU12662 | ||||||
AUC 24,ss (ng*hr/mL) | 520 (474–571) | 567 (522–617) | 492 (458–529) | 354 (174–720)* | 597 (457–779) | 492 (435–555) |
CL/F (L/hr) | 20.2 (18.4 - 22.1) | 18.5 (17.0 - 20.1) | 21.4 (19.9 - 23.0) | 29.7 (14.6 - 60.4)* | 17.6 (13.5 - 23.0) | 21.4 (18.9 - 24.1) |