Table 4 Univariate and multivariate analyses of the prognostic factors for 5-year OS of CRC patients (n = 342)

T stage

  T1-T2

79%

0.009

NS

  T3-T4

64%

N stage

  N0

78%

<0.0001

NS

  N1-N2

61%

M stage

  M0

73%

<0.0001

NS

  M1

23%

Differentiation grade

  Well

74%

0.004

NS

  Moderately

72%

  Poorly

47%

TNM stage

  I

86%

<0.0001

1

Reference

<0.0001

  II

78%

1.016

0.411-2.511

  III

69%

1.674

0.686-4.083

  IV

22%

9.685

3.773-24.862

CEA(ug/L)

  ≤5

80%

<0.0001

1

Reference

0.006

  >5

54%

1.144

0.465-2.811

CA19-9 (ug/L)

0.040

  ≤60

72%

NS

  >60

59%

ADAM8 protein

  Negative

81%

0.037

1

Reference

0.024

  Positive

67%

1.943

1.089-3.465