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Table 2 Correlation between coagulation variables and clinicopathological characteristics in GBC patients

From: Clinical and prognostic significance of preoperative plasma hyperfibrinogenemia in gallbladder cancer patients following surgical resection: a retrospective and in vitro study

Variable

N

Coagulation tests

  

PT (s)

aPTT (s)

TT (s)

INR

Fibrinogen (mg/dL)

PLT (×104/mm3)

Gender

       

Male

37 (32.2%)

11.7 (1.6)

29.2 (5.1)

14.5 (3.0)

1.3 (1.5)

423.7 (127.3)

212.0 (79.6)

Female

78 (67.8%)

11.6 (1.2)

27.2 (4.4)

15.8 (3.6)

1.0 (0.1)

398.2 (118.0)

226.3 (69.6)

  

(p = 0.642)

(p = 0.028)

(p = 0.126)

(p = 0.323)

(p = 0.293)

(p = 0.330)

Age (years)

       

<60

29 (25.2%)

11.3 (1.2)

28.2 (5.0)

14.2 (2.9)

1.0 (1.0)

373.7 (136.2)

223.6 (72.9)

≥60

86 (74.8%)

11.7 (1.4)

27.7 (4.6)

15.8 (3.5)

1.1 (1.0)

417.5 (114.3)

221.1 (73.4)

  

(p = 0.123)

(p = 0.650)

(p = 0.651)

(p = 0.490)

(p = 0.653)

(p = 0.874)

Histologic differentiation

       

Well

15 (13.0%)

11.4 (1.0)

28.0 (4.6)

16.4 (3.3)

1.6 (0.9)

357.1 (86.4)

214.7 (61.6)

Moderate

59 (51.3%)

11.5 (1.3)

27.5 (5.1)

15.0 (2.7)

1.0 (0.1)

381.5 (116.3)

214.9 (74.1)

Poor

40 (34.8%)

11.7 (1.4)

28.0 (4.1)

15.3 (4.2)

1.1 (0.1)

454.3 (116.6)

231.0 (73.5)

Undifferentiated

1 (0.9%)

      
  

(p = 0.593)

(p = 0.842)

(p = 0.480)

(p = 0.060)*

(p = 0.002) **

(p = 0.526)

Tumor invasion

       

Tis-T1

18 (0.2%)

11.9 (1.5)

28.7 (5.1)

17.0 (3.2)

1.0 (0.1)

349.9 (68.7)

210.6 (63.9)

T2-T4

95 (0.8%)

11.5 (1.3)

27.8 (4.7)

14.9 (3.4)

1.1 (1.0)

421.9 (127.1)

223.1 (75.0)

Not available

2 (0.0%)

      
  

(p = 0.262)

(p = 0.423)

(p = 0.038)

(p = 0.643)

(p = 0.016)

(p = 0.509)

Lymph node metastasis

       

Absent

73 (63.5%)

11.6 (1.3)

27.8 (4.8)

15.7 (3.2)

1.2 (1.1)

382.7 (116.0)

208.5 (64.5)

Present

42 (36.5%)

11.5 (1.5)

27.9 (4.6)

14.7 (3.8)

1.0 (0.1)

447.7 (120.0)

244.7 (81.4)

  

(p = 0.759)

(p = 0.917)

(p = 0.223)

(p = 0.524)

(p = 0.005)

(p = 0.010)

TNM stage

       

0-I

22 (19.1%)

11.9 (1.3)

27.7 (5.1)

16.9 (3.2)

1.0 (0.1)

331.4 (86.3)

208.6 (67.0)

II-IV

93 (80.9%)

11.5 (1.3)

27.9 (4.6)

14.9 (3.4)

1.1 (1.0)

432.9 (120.9)

224.8 (74.3)

  

(p = 0.260)

(p = 0.891)

(p = 0.057)

(p = 0.616)

(p < 0.001)

(p = 0.353)

  1. GBC, gallbladder carcinoma; PT, prothrombin time; aPTT, activated partial prothromboplastin time; TT, thrombin time; INR, international normalized ratio; PLT, platelets.
  2. Bold italics indicate statistically significant values (p < 0.05).
  3. *For Well vs. Moderate, p = 0.021; Moderate vs. Poor, p = 0.870; Well vs. Poor, p = 0.036.
  4. **For Well vs. Moderate, p = 0.458; Moderate vs. Poor, p = 0.002; Well vs. Poor, p = 0.005.
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