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Table 2 Main advantages and weaknesses of the two control groups

From: Studying the impact of early life exposures to pesticides on the risk of testicular germ cell tumors during adulthood (TESTIS project): study protocol

  Advantages Weaknesses
Control Group A (sperm donators & fertile partners of infertile woman) - Direct access to the subject (face to face recruitment & blood sampling) - Older than cases/difficult to recruit subjects below 25 years old
- More concerned by the topic/good participation rate - Live with infertile woman/more exposed to reproductive toxicant than general population?
- Sperm count available
- Regional recruitment
Control Group B (partners of pregnant woman hospitalized for pathological pregnancy) - Same age group than cases - More difficult to approach (visit during evening/week-end)
- Direct access to the subject (face to face recruitment & blood sampling)
- Presumably fecund - No available serologies (need to store blood samples in separate areas)
- Regional recruitment - Link between subjects’ exposures partners’ pathological pregnancy?
  - Large population/easy to match with cases