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Figure 3 | BMC Cancer

Figure 3

From: ΔNp63α enhances the oncogenic phenotype of osteosarcoma cells by inducing the expression of GLI2

Figure 3

Microarray analysis to detect differential gene expression in SaOS-2- ΔNp63α cells. Hierarchical clustering of differentially expressed genes revealed by microarray analysis in SaOS-2- ΔNp63αcells compared with SaOS-2-EV cells. The heat maps depict the fold-change of up- (A) and down-regulated (C) genes in SaOS-2-ΔNp62α compared with SaOS-2-EV cells in descending order of 10 to 3. Quantitative RT-PCR validation of the microarray results obtained for indicated up (B) and down-regulated (D) genes. E. Transcript enrichment in SaOS-2-ΔNp63α cells grouped by functional related terms from the KEGG pathway analysis. F. Genes enriched in Hh signaling pathway are highlighted.

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