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Table 4 Multivariable analysis of cause-specific survival in patients with middle ear cancer

From: Prognostic models to predict overall and cause-specific survival for patients with middle ear cancer: a population-based analysis

 

Full model

Reduced model

Covariate

HR

95% CI

P-value

HR

95% CI

P-value

Age (70:45)

1.66

1.16-2.38

0.004*

1.70

1.19-2.45

0.002*

Sex

      

  Male

1

  

-

  

  Female

1.37

0.89-2.11

0.15

-

-

-

Race

      

  White

1

  

-

  

  Non White

0.80

0.47-1.38

0.42

-

-

-

Year of diagnosis (2000:1990)

0.80

0.61-1.05

0.11

-

-

-

Stage

      

  Localized

1

  

1

  

  Regional

2.93

1.43-6.00

0.003*

2.93

1.43-5.99

0.003*

  Distant

4.88

2.20-10.82

<0.001*

4.82

2.17-10.69

<0.001*

Radiation

      

  No

1

  

1

  

  Yes

1.84

1.07-3.15

0.03*

2.14

1.28-3.58

0.004*

Histological types#

-

-

0.003*

-

-

0.004*

Surgery#

-

-

0.06

-

-

0.05

Histology × surgery

-

-

0.03*

-

-

0.02*

Surgery

      

  Squamous cell carcinoma

1

  

1

  

  Adenocarcinoma

0.16

0.06-0.46

<0.001*

0.18

0.06-0.50

0.001*

  Others

0.55

0.27-1.12

0.10

0.60

0.30-1.19

0.15

No surgery

      

  Squamous cell carcinoma

1

  

1

  

  Adenocarcinoma

1.95

0.40-9.51

0.41

2.33

0.47-11.68

0.30

  Others

0.51

0.19-1.39

0.19

0.54

0.20-1.46

0.22

  1. Abbreviations: HR Hazard Ratio, CI Confidence Interval.
  2. #Hazard ratios for histology type are presented by surgery because of the significant interaction between these two covariates.
  3. *P <0.05.