|
Cell-cell adhesion genes
|
Cell-ECM adhesion genes
|
Focal adhesion genes
|
|---|
|
Gene
|
FC
|
Adj. p value
|
Gene
|
FC
|
Adj. p value
|
Gene
|
FC
|
Adj. p value
|
|
CLDN1
|
3.1
|
3.45E-05
|
COL2A1
|
5.3
|
3.22E-04
|
TLN1
|
-1.5
|
1.48E-02
|
|
CLDN4
|
3.8
|
4.87E-05
|
COL4A1
|
-2.6
|
3.45E-05
|
TLN2
|
-2.0
|
5.72E-03
|
|
CLDN7
|
2.7
|
1.51E-05
|
COL4A2
|
-2.5
|
4.88E-05
|
TNS1
|
-5.5
|
7.34E-05
|
|
OCLN
|
2.9
|
2.27E-05
|
COL4A4
|
-2.9
|
2.04E-02
|
TNS3
|
-2.3
|
2.77E-04
|
|
CRB3
|
2.1
|
5.38E-04
|
COL5A3
|
3.6
|
1.07E-03
|
UTRN
|
-2.4
|
1.13E-02
|
|
CGN
|
3.0
|
1.80E-04
|
COL6A3
|
-3.5
|
2.86E-03
|
DLC1
|
-2.2
|
1.19E-03
|
|
(CDH1)
|
-10.0
|
9.10E-06
|
COL7A1
|
2.0
|
3.11E-03
|
ACTN1
|
1.0
|
4.98E-01
|
|
CDH2
|
-2.2
|
2.37E-04
|
COL8A1
|
-6.3
|
1.12E-05
|
ACTN4
|
1.1
|
3.03E-01
|
|
CDH3
|
1.8
|
1.51E-05
|
COL12A1
|
-4.3
|
4.48E-04
|
VCL
|
-1.1
|
4.20E-01
|
|
CDH4
|
-2.9
|
7.79E-04
|
COL13A1
|
6.1
|
1.07E-04
|
ACTB
|
1.2
|
2.66E-02
|
|
CDH16
|
3.8
|
6.73E-04
|
COL18A1
|
-2.4
|
4.07E-04
|
ACTG1
|
1.3
|
8.62E-04
|
|
PVRL4
|
2.2
|
1.01E-04
|
COL27A1
|
-6.3
|
7.07E-04
|
TUBB2A
|
1.3
|
6.73E-03
|
|
DSG4
|
3.0
|
9.73E-04
|
COL28A1
|
-34.1
|
4.93E-03
|
PTK2
|
1.1
|
1.48E-02
|
|
DSC2
|
2.2
|
2.87E-05
|
LAMA1
|
-2.5
|
8.51E-04
|
SRC
|
-1.3
|
2.29E-02
|
|
JUP
|
2.0
|
8.71E-06
|
LAMA2
|
2.3
|
4.77E-04
|
ILK
|
1.0
|
4.20E-01
|
|
GJA5
|
2.1
|
1.13E-02
|
FN1
|
-7.2
|
1.78E-04
|
RAC1
|
1.1
|
2.29E-02
|
|
GJB2
|
3.9
|
3.88E-06
|
ITGA1
|
-2.8
|
6.37E-04
|
RHOA
|
1.1
|
1.89E-02
|
|
GJB4
|
3.2
|
7.10E-04
|
ITGA10
|
2.0
|
6.92E-04
|
ROCK1
|
-1.3
|
4.28E-02
|
|
ICAM1
|
-3.6
|
8.31E-03
|
ITGB1
|
-1.4
|
2.91E-04
|
PXN
|
-1.1
|
1.65E-02
|
- The CDH1 transcript level in MCF10A CDH1-/- cells was markedly reduced by more than 90% compared to the wild type CDH1 transcript in MCF10A cells, consistent with nonsense-mediated decay. The table contains a selection of genes involved in cell-cell adhesion, cell-ECM adhesion and focal adhesion including genes with a significant fold change ≥2.0. Other genes with fold change <2.0 are listed in the Additional file 4: Table S2 and Additional file 5: Table S3. FC denotes the fold change relative to MCF10A wildtype expression.
