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Table 1 Expression profile of cell adhesion genes in MCF10A CDH1-/-

From: E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition

Cell-cell adhesion genes Cell-ECM adhesion genes Focal adhesion genes
Gene FC Adj. p value Gene FC Adj. p value Gene FC Adj. p value
CLDN1 3.1 3.45E-05 COL2A1 5.3 3.22E-04 TLN1 -1.5 1.48E-02
CLDN4 3.8 4.87E-05 COL4A1 -2.6 3.45E-05 TLN2 -2.0 5.72E-03
CLDN7 2.7 1.51E-05 COL4A2 -2.5 4.88E-05 TNS1 -5.5 7.34E-05
OCLN 2.9 2.27E-05 COL4A4 -2.9 2.04E-02 TNS3 -2.3 2.77E-04
CRB3 2.1 5.38E-04 COL5A3 3.6 1.07E-03 UTRN -2.4 1.13E-02
CGN 3.0 1.80E-04 COL6A3 -3.5 2.86E-03 DLC1 -2.2 1.19E-03
(CDH1) -10.0 9.10E-06 COL7A1 2.0 3.11E-03 ACTN1 1.0 4.98E-01
CDH2 -2.2 2.37E-04 COL8A1 -6.3 1.12E-05 ACTN4 1.1 3.03E-01
CDH3 1.8 1.51E-05 COL12A1 -4.3 4.48E-04 VCL -1.1 4.20E-01
CDH4 -2.9 7.79E-04 COL13A1 6.1 1.07E-04 ACTB 1.2 2.66E-02
CDH16 3.8 6.73E-04 COL18A1 -2.4 4.07E-04 ACTG1 1.3 8.62E-04
PVRL4 2.2 1.01E-04 COL27A1 -6.3 7.07E-04 TUBB2A 1.3 6.73E-03
DSG4 3.0 9.73E-04 COL28A1 -34.1 4.93E-03 PTK2 1.1 1.48E-02
DSC2 2.2 2.87E-05 LAMA1 -2.5 8.51E-04 SRC -1.3 2.29E-02
JUP 2.0 8.71E-06 LAMA2 2.3 4.77E-04 ILK 1.0 4.20E-01
GJA5 2.1 1.13E-02 FN1 -7.2 1.78E-04 RAC1 1.1 2.29E-02
GJB2 3.9 3.88E-06 ITGA1 -2.8 6.37E-04 RHOA 1.1 1.89E-02
GJB4 3.2 7.10E-04 ITGA10 2.0 6.92E-04 ROCK1 -1.3 4.28E-02
ICAM1 -3.6 8.31E-03 ITGB1 -1.4 2.91E-04 PXN -1.1 1.65E-02
  1. The CDH1 transcript level in MCF10A CDH1-/- cells was markedly reduced by more than 90% compared to the wild type CDH1 transcript in MCF10A cells, consistent with nonsense-mediated decay. The table contains a selection of genes involved in cell-cell adhesion, cell-ECM adhesion and focal adhesion including genes with a significant fold change ≥2.0. Other genes with fold change <2.0 are listed in the Additional file 4: Table S2 and Additional file 5: Table S3. FC denotes the fold change relative to MCF10A wildtype expression.