Table 1 Expression profile of cell adhesion genes in MCF10A CDH1-/-
Cell-cell adhesion genes | Cell-ECM adhesion genes | Focal adhesion genes | ||||||
|---|---|---|---|---|---|---|---|---|
Gene | FC | Adj. p value | Gene | FC | Adj. p value | Gene | FC | Adj. p value |
CLDN1 | 3.1 | 3.45E-05 | COL2A1 | 5.3 | 3.22E-04 | TLN1 | -1.5 | 1.48E-02 |
CLDN4 | 3.8 | 4.87E-05 | COL4A1 | -2.6 | 3.45E-05 | TLN2 | -2.0 | 5.72E-03 |
CLDN7 | 2.7 | 1.51E-05 | COL4A2 | -2.5 | 4.88E-05 | TNS1 | -5.5 | 7.34E-05 |
OCLN | 2.9 | 2.27E-05 | COL4A4 | -2.9 | 2.04E-02 | TNS3 | -2.3 | 2.77E-04 |
CRB3 | 2.1 | 5.38E-04 | COL5A3 | 3.6 | 1.07E-03 | UTRN | -2.4 | 1.13E-02 |
CGN | 3.0 | 1.80E-04 | COL6A3 | -3.5 | 2.86E-03 | DLC1 | -2.2 | 1.19E-03 |
(CDH1) | -10.0 | 9.10E-06 | COL7A1 | 2.0 | 3.11E-03 | ACTN1 | 1.0 | 4.98E-01 |
CDH2 | -2.2 | 2.37E-04 | COL8A1 | -6.3 | 1.12E-05 | ACTN4 | 1.1 | 3.03E-01 |
CDH3 | 1.8 | 1.51E-05 | COL12A1 | -4.3 | 4.48E-04 | VCL | -1.1 | 4.20E-01 |
CDH4 | -2.9 | 7.79E-04 | COL13A1 | 6.1 | 1.07E-04 | ACTB | 1.2 | 2.66E-02 |
CDH16 | 3.8 | 6.73E-04 | COL18A1 | -2.4 | 4.07E-04 | ACTG1 | 1.3 | 8.62E-04 |
PVRL4 | 2.2 | 1.01E-04 | COL27A1 | -6.3 | 7.07E-04 | TUBB2A | 1.3 | 6.73E-03 |
DSG4 | 3.0 | 9.73E-04 | COL28A1 | -34.1 | 4.93E-03 | PTK2 | 1.1 | 1.48E-02 |
DSC2 | 2.2 | 2.87E-05 | LAMA1 | -2.5 | 8.51E-04 | SRC | -1.3 | 2.29E-02 |
JUP | 2.0 | 8.71E-06 | LAMA2 | 2.3 | 4.77E-04 | ILK | 1.0 | 4.20E-01 |
GJA5 | 2.1 | 1.13E-02 | FN1 | -7.2 | 1.78E-04 | RAC1 | 1.1 | 2.29E-02 |
GJB2 | 3.9 | 3.88E-06 | ITGA1 | -2.8 | 6.37E-04 | RHOA | 1.1 | 1.89E-02 |
GJB4 | 3.2 | 7.10E-04 | ITGA10 | 2.0 | 6.92E-04 | ROCK1 | -1.3 | 4.28E-02 |
ICAM1 | -3.6 | 8.31E-03 | ITGB1 | -1.4 | 2.91E-04 | PXN | -1.1 | 1.65E-02 |