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Table 2 Drug sensitivity of CEM cells after the loss of mitochondrial DNA

From: Reduced drug incorporation into DNA and antiapoptosis as the crucial mechanisms of resistance in a novel nelarabine-resistant cell line

  IC50(μM)
Drug CEM ρ0CEM
Ara-G 3.5 4.0
  1. CEM cells and mitochondria-depleted ρ0CEM cells were incubated for 72 h with various concentrations of ara-G. The IC50 was then determined by using the ATP-based assay.