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Table 2 Drug sensitivity of CEM cells after the loss of mitochondrial DNA

From: Reduced drug incorporation into DNA and antiapoptosis as the crucial mechanisms of resistance in a novel nelarabine-resistant cell line

 

IC50(μM)

Drug

CEM

ρ0CEM

Ara-G

3.5

4.0

  1. CEM cells and mitochondria-depleted ρ0CEM cells were incubated for 72 h with various concentrations of ara-G. The IC50 was then determined by using the ATP-based assay.