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Table 1 Drug sensitivities of CEM and CEM/ara-G cells

From: Reduced drug incorporation into DNA and antiapoptosis as the crucial mechanisms of resistance in a novel nelarabine-resistant cell line

Drug IC50(μM)
CEM CEM/ara-G RR
Ara-G 2.6 180 (70)
F-ara-A 0.10 4.80 (48)
Ara-C 0.15 0.75 (5)
  1. CEM and CEM/ara-G cells were incubated for 72 h with various concentrations of ara-G, ara-C, or F-ara-A. The IC50 was then determined by using the XTT assay. The number in the parenthesis is the relative resistance (RR), which was obtained by dividing the IC50 value of CEM/ara-G cells by that of CEM cells.