Apoptosis inhibitor-5 overexpression is associated with tumor progression and poor prognosis in patients with cervical cancer

Table 3 Univariate and multivariate analyses of the associations between prognostic variables and overall survival in 173 cases of cervical cancer

Variables	Overall survival hazard ratio [95% CI], Pvalue		Disease-free survival hazard ratio [95% CI], Pvalue
Variables	Univariate analysis	Multivariate analysis	Univariate analysis	Multivariate analysis
FIGO stage (≥IIb)	3.10 [1.19-8.07], 0.020	1.62 [0.32-8.15], 0.557	5.74 [2.89-11.41], <0.001	5.86 [2.00-17.18], 0.001
Cell type (SCC)	0.30 [0.11-0.79], 0.015	0.23 [0.06-0.80], 0.021	0.84 [0.36-1.94], 0.695	NS
Tumor grade (poor)	2.75 [1.05-7.25], 0.040	1.80 [0.52-6.25], 0.353	2.09 [1.06-4.10], 0.031	1.05 [0.44-2.51], 0.901
Tumor size (>4 cm)	1.71 [0.65-4.51], 0.273	NS	2.54 [1.29-4.97], 0.007	1.28 [0.54-3.00], 0.568
LN metastasis	6.30 [2.10-18.87], 0.001	3.85 [1.08-13.73], 0.038	5.15 [2.38-11.13], <0.001	2.49 [1.02-6.17], 0.047
API5+ (≥8)	5.74 [1.82-18.05], 0.003	3.98 [1.07-14.85], 0.039	3.10 [1.52-6.34], 0.002	2.74 [1.09-6.85], 0.031
pERK1/2+ (≥4)	2.69 [1.00-7.23], 0.049	2.33 [0.65-8.32], 0.193	1.74 [0.86-3.51], 0.117	NS
API5+/pERK1/2+	5.02 [1.91-13.22], 0.001	4.14 [1.12-15.21], 0.032	4.56 [2.25-9.24], <0.001	3.99 [1.47-10.87], 0.007

FIGO, International Federation of Gynecology and Obstetrics; SCC, squamous cell carcinoma; LN, lymph node; NS, not significant.

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