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Table 3 Univariate and multivariate analyses of the associations between prognostic variables and overall survival in 173 cases of cervical cancer

From: Apoptosis inhibitor-5 overexpression is associated with tumor progression and poor prognosis in patients with cervical cancer

Variables Overall survival hazard ratio [95% CI], Pvalue Disease-free survival hazard ratio [95% CI], Pvalue
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
FIGO stage (≥IIb) 3.10 [1.19-8.07], 0.020 1.62 [0.32-8.15], 0.557 5.74 [2.89-11.41], <0.001 5.86 [2.00-17.18], 0.001
Cell type (SCC) 0.30 [0.11-0.79], 0.015 0.23 [0.06-0.80], 0.021 0.84 [0.36-1.94], 0.695 NS
Tumor grade (poor) 2.75 [1.05-7.25], 0.040 1.80 [0.52-6.25], 0.353 2.09 [1.06-4.10], 0.031 1.05 [0.44-2.51], 0.901
Tumor size (>4 cm) 1.71 [0.65-4.51], 0.273 NS 2.54 [1.29-4.97], 0.007 1.28 [0.54-3.00], 0.568
LN metastasis 6.30 [2.10-18.87], 0.001 3.85 [1.08-13.73], 0.038 5.15 [2.38-11.13], <0.001 2.49 [1.02-6.17], 0.047
API5+ (≥8) 5.74 [1.82-18.05], 0.003 3.98 [1.07-14.85], 0.039 3.10 [1.52-6.34], 0.002 2.74 [1.09-6.85], 0.031
pERK1/2+ (≥4) 2.69 [1.00-7.23], 0.049 2.33 [0.65-8.32], 0.193 1.74 [0.86-3.51], 0.117 NS
API5+/pERK1/2+ 5.02 [1.91-13.22], 0.001 4.14 [1.12-15.21], 0.032 4.56 [2.25-9.24], <0.001 3.99 [1.47-10.87], 0.007
  1. FIGO, International Federation of Gynecology and Obstetrics; SCC, squamous cell carcinoma; LN, lymph node; NS, not significant.