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Table 1 Expression of API5 and pERK1/2 in relation to clinicopathologic characteristics in IHC analysis

From: Apoptosis inhibitor-5 overexpression is associated with tumor progression and poor prognosis in patients with cervical cancer

   API5    pERK1/2  
No. % Mean scores (95% CI) P value No. % Mean scores (95% CI) P value
All study subjects 850 100 3.53 (3.35-3.71)   793 100 2.45 (2.27-2.63)  
Diagnostic category     <0.001     <0.001
Normal 411 48.3 2.44 (2.23-2.65)   382 48.1 1.69 (1.54-1.85)  
Low grade CIN 67 7.9 3.79 (3.23-4.36)   57 7.2 2.65 (2.17-3.13)  
High grade CIN 220 25.9 4.19 (3.88-4.50)   204 25.7 3.32 (2.95-3.69)  
Cancer 152 17.9 5.39 (4.92-5.87)   150 19.0 3.13 (2.53-3.73)  
FIGO stage     0.004     0.205
I 102 67.1 4.88 (4.35-5.42)   99 66.0 2.89 (2.16-3.62)  
II 41 27.0 6.17 (5.14-7.20)   44 29.3 3.30 (2.19-4.40)  
IV 9 5.9 7.67 (5.39-9.94)   7 4.7 5.43 (1.06-9.79)  
Cell type     0.533     0.114
SCC 122 80.3 5.32 (4.78-5.86)   124 82.7 3.35 (2.65-4.04)  
Others 30 19.7 5.70 (4.58-6.82)   26 17.3 2.08 (1.09-3.07)  
Tumor grade     <0.001     0.237
Well + Moderate 94 64.4 4.69 (4.12-5.26)   96 65.3 2.78 (2.07-3.49)  
Poor 52 35.6 6.62 (5.80-7.44)   51 34.7 3.53 (2.44-4.62)  
Tumor size     0.932     0.776
≤ 4 cm 105 69.1 5.38 (4.82-5.94)   103 68.7 3.07 (2.37-3.77)  
> 4 cm 47 30.9 5.43 (4.47-6.38)   47 31.3 3.26 (2.07-4.44)  
LN metastasis     0.385     0.637
No 104 76.5 5.00 (4.45-5.55)   102 75.0 2.71 (2.02-3.40)  
Yes 32 23.5 5.53 (4.24-6.82)   34 25.0 2.38 (1.25-3.52)  
Chemoradiation     0.004     0.216
Good response 29 80.6 3.41 (2.27-4.56)   31 81.6 1.39 (0.66-2.11)  
Bad response 7 19.4 7.00 (5.81-8.19)   7 18.4 0.43 (-0.07-0.92)  
HPV test in CIN     0.951     0.940
Negative 28 12.4 4.14 (3.19-5.10)   28 13.7 3.07 (2.12-4.02)  
Positive 198 87.6 4.17 (3.85-4.49)   177 86.3 3.11 (2.76-3.45)  
  1. CIN, cervical intraepithelial neoplasia; FIGO, International Federation of Gynecology and Obstetrics; SCC, squamous cell carcinoma; LN, lymph node; HPV, human papillomavirus.