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Table 1 Expression of API5 and pERK1/2 in relation to clinicopathologic characteristics in IHC analysis

From: Apoptosis inhibitor-5 overexpression is associated with tumor progression and poor prognosis in patients with cervical cancer

  

API5

  

pERK1/2

 

No.

%

Mean scores (95% CI)

P value

No.

%

Mean scores (95% CI)

P value

All study subjects

850

100

3.53 (3.35-3.71)

 

793

100

2.45 (2.27-2.63)

 

Diagnostic category

   

<0.001

   

<0.001

Normal

411

48.3

2.44 (2.23-2.65)

 

382

48.1

1.69 (1.54-1.85)

 

Low grade CIN

67

7.9

3.79 (3.23-4.36)

 

57

7.2

2.65 (2.17-3.13)

 

High grade CIN

220

25.9

4.19 (3.88-4.50)

 

204

25.7

3.32 (2.95-3.69)

 

Cancer

152

17.9

5.39 (4.92-5.87)

 

150

19.0

3.13 (2.53-3.73)

 

FIGO stage

   

0.004

   

0.205

I

102

67.1

4.88 (4.35-5.42)

 

99

66.0

2.89 (2.16-3.62)

 

II

41

27.0

6.17 (5.14-7.20)

 

44

29.3

3.30 (2.19-4.40)

 

IV

9

5.9

7.67 (5.39-9.94)

 

7

4.7

5.43 (1.06-9.79)

 

Cell type

   

0.533

   

0.114

SCC

122

80.3

5.32 (4.78-5.86)

 

124

82.7

3.35 (2.65-4.04)

 

Others

30

19.7

5.70 (4.58-6.82)

 

26

17.3

2.08 (1.09-3.07)

 

Tumor grade

   

<0.001

   

0.237

Well + Moderate

94

64.4

4.69 (4.12-5.26)

 

96

65.3

2.78 (2.07-3.49)

 

Poor

52

35.6

6.62 (5.80-7.44)

 

51

34.7

3.53 (2.44-4.62)

 

Tumor size

   

0.932

   

0.776

≤ 4 cm

105

69.1

5.38 (4.82-5.94)

 

103

68.7

3.07 (2.37-3.77)

 

> 4 cm

47

30.9

5.43 (4.47-6.38)

 

47

31.3

3.26 (2.07-4.44)

 

LN metastasis

   

0.385

   

0.637

No

104

76.5

5.00 (4.45-5.55)

 

102

75.0

2.71 (2.02-3.40)

 

Yes

32

23.5

5.53 (4.24-6.82)

 

34

25.0

2.38 (1.25-3.52)

 

Chemoradiation

   

0.004

   

0.216

Good response

29

80.6

3.41 (2.27-4.56)

 

31

81.6

1.39 (0.66-2.11)

 

Bad response

7

19.4

7.00 (5.81-8.19)

 

7

18.4

0.43 (-0.07-0.92)

 

HPV test in CIN

   

0.951

   

0.940

Negative

28

12.4

4.14 (3.19-5.10)

 

28

13.7

3.07 (2.12-4.02)

 

Positive

198

87.6

4.17 (3.85-4.49)

 

177

86.3

3.11 (2.76-3.45)

 
  1. CIN, cervical intraepithelial neoplasia; FIGO, International Federation of Gynecology and Obstetrics; SCC, squamous cell carcinoma; LN, lymph node; HPV, human papillomavirus.
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