Skip to main content
Figure 11 | BMC Cancer

Figure 11

From: Hypoxia represses microRNA biogenesis proteins in breast cancer cells

Figure 11

miRNA processing is affected by hypoxia. Luciferase activity in SKBR3 cells after co-transfection with RL reporter containing a ZEB1 WT with miR-200b target sites (pCi-neo-ZEB1-hRL) and precursor miR-200b (pCMV-miR-200b) or empty vector (pCMV-miR) (Origene), then exposure to hypoxia (0.1% O2 24 h) vs. normoxia (P = 0.04). *denotes P < 0.05 compared with parallel controls. Data represent normalized mean ± S.E (error bars) from two independent experiments consisting of three technical replicates.

Back to article page