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Table 2 Survival analyses single markers in TNM stage I and II colon cancer patients

From: Histone trimethylation at H3K4, H3K9 and H4K20 correlates with patient survival and tumor recurrence in early-stage colon cancer

   OS DSS LRRFS DRFS
H3K4me3
Univariate p-value 0.4 0.02 0.01 0.01
  HR 1.26 4.45 3.54 3.63
  (95% CI) (0.75-2.11) (1.29-15.38) (1.32-9.49) (1.36-9.73)
Multivariate p-value 0.3 0.04 0.01 0.01
  HR 1.36 3.79 3.86 3.57
  (95% CI) (0.79-2.33) (1.06-13.56) (1.38-10.77) (1.29-9.81)
5-year survival rates Low expression 73% 95% 93% 94%
High expression 76% 82% 74% 77%
H3K9me3
Univariate p-value 0.07 0.02 0.07 0.02
  HR 0.61 0.30 0.47 0.36
  (95% CI) (0.36-1.04) (0.12-0.86) (0.21-1.08) (0.16-0.85)
Multivariate p-value 0.2 0.01 0.05 0.01
  HR 0.69 0.26 0.42 0.29
  (95% CI) (0.39-1.24) (0.09-0.77) (0.17-1.01) (0.12-0.75)
5-year survival rates Low expression 64% 78% 71% 74%
High expression 86% 96% 92% 92%
H4K20me3
Univariate p-value 0.1 0.01 0.02 0.04
  HR 0.67 0.24 0.34 0.41
  (95% CI) (0.40-1.12) (0.08-0.72) (0.14-0.81) (0.18-0.95)
Multivariate p-value 0.02 0.02 0.008 0.01
  HR 0.51 0.21 0.29 0.31
  (95% CI) (0.29-0.89) (0.06-0.67) (0.12-0.72) (0.13-0.77)
5-year survival rates Low expression 67% 80% 74% 77%
High expression 80% 94% 90% 91%
  1. Shown are the results of the univariate and multivariate analyses of all individual markers in TNM stage I and II colon cancer patients, with all p-values and hazard ratios (HR) with their 95% confidence intervals (95% CI). OS = overall survival, DSS = disease-specific survival, LRRFS = locoregional recurrence free survival, DRFS = distant recurrence free survival. The low expression group (below-median expression) was used as reference group. 5-year survival rates are given for both low and high expression groups. Statistically significant differences (defined as p < 0.05) are shown in bold, trends (p < 0.1) in Italic.