Histone trimethylation at H3K4, H3K9 and H4K20 correlates with patient survival and tumor recurrence in early-stage colon cancer

Table 2 Survival analyses single markers in TNM stage I and II colon cancer patients

		OS	DSS	LRRFS	DRFS
H3K4me3
Univariate	p-value	0.4	0.02	0.01	0.01
	HR	1.26	4.45	3.54	3.63
	(95% CI)	(0.75-2.11)	(1.29-15.38)	(1.32-9.49)	(1.36-9.73)
Multivariate	p-value	0.3	0.04	0.01	0.01
	HR	1.36	3.79	3.86	3.57
	(95% CI)	(0.79-2.33)	(1.06-13.56)	(1.38-10.77)	(1.29-9.81)
5-year survival rates	Low expression	73%	95%	93%	94%
5-year survival rates	High expression	76%	82%	74%	77%
H3K9me3
Univariate	p-value	0.07	0.02	0.07	0.02
	HR	0.61	0.30	0.47	0.36
	(95% CI)	(0.36-1.04)	(0.12-0.86)	(0.21-1.08)	(0.16-0.85)
Multivariate	p-value	0.2	0.01	0.05	0.01
	HR	0.69	0.26	0.42	0.29
	(95% CI)	(0.39-1.24)	(0.09-0.77)	(0.17-1.01)	(0.12-0.75)
5-year survival rates	Low expression	64%	78%	71%	74%
5-year survival rates	High expression	86%	96%	92%	92%
H4K20me3
Univariate	p-value	0.1	0.01	0.02	0.04
	HR	0.67	0.24	0.34	0.41
	(95% CI)	(0.40-1.12)	(0.08-0.72)	(0.14-0.81)	(0.18-0.95)
Multivariate	p-value	0.02	0.02	0.008	0.01
	HR	0.51	0.21	0.29	0.31
	(95% CI)	(0.29-0.89)	(0.06-0.67)	(0.12-0.72)	(0.13-0.77)
5-year survival rates	Low expression	67%	80%	74%	77%
5-year survival rates	High expression	80%	94%	90%	91%

Shown are the results of the univariate and multivariate analyses of all individual markers in TNM stage I and II colon cancer patients, with all p-values and hazard ratios (HR) with their 95% confidence intervals (95% CI). OS = overall survival, DSS = disease-specific survival, LRRFS = locoregional recurrence free survival, DRFS = distant recurrence free survival. The low expression group (below-median expression) was used as reference group. 5-year survival rates are given for both low and high expression groups. Statistically significant differences (defined as p < 0.05) are shown in bold, trends (p < 0.1) in Italic.

ISSN: 1471-2407