Lenvatinib treatment-dependent changes in VEGF, SDF1α, and sVEGFR2. The concentrations of plasma VEGF (A), SDF1α (C), and sVEGFR2 (E) were measured at baseline and at day 8 of lenvatinib treatment, and the percentage change from baseline was plotted in correlation with AUC0-tau. The correlation coefficient (r) and P value in each analysis are indicated. The percentage PD changes in VEGF (B), SDF1α (D), and sVEGFR2 (F) relative to dosing schedule were indicated for 14 days on treatment (at days [D] 8 and 15 of cycle [C] 1), after 7 days off treatment, and on retreatment in cycle 2. A dotted line indicates the mean percentage of change, and gray boxes indicate each on-treatment period.