Table 3 Published information about validated microRNA target genes and implication in cancer
From: MicroRNA profile in very young women with breast cancer
miRNAs | Gene | Target/Function | Published papers |
|---|---|---|---|
miR-1228 | MOAP1 | Bcl homologous. When repressed, allows cells to escape from apoptosis. | Yan et al. Apoptosis. 2012 [69] |
miR-3196 | PAX2, THTPA, PIK3R2, BBC3 | PAX2 . Implicated in suppression of translation (through WT1). Associated to low breast cancer risk. Repression of PAX2 would promote a more aggressive breast cancer. THTPA. Metastasis tumour suppressor. PIK3R2 . Proliferation pathway. Anti-apoptotic. BBC3 . Pro-apoptotic gene and associated to tumour size. | Beauchemin et al. Molecular Cancer. 2011 [53]. Kovacevic et al. Biochem Biophys Acta. 2008 [58]. Tajnik et al. Cancer Biomarkers. 2012 [66]. Wong et al. PlosOne. 2012 [68] |
miR-1275 | IGF1, NFIX, Claudin11 | IGF1 related to tumour proliferation. NFIX hypermethylated in breast cancer lines. Claudin 11, cellular adhesion molecule, associated to invasion and capacity of metastasis when downregulated. | Castaño et al. Cancer Discovery. 2013 [54]. Awsare,et al. Oncology reports. 2011 [51]. Webb et al. BMC Cell Biol. 2013 [67]. Özata et al. Endocr Relat Cancer .2011 [62]. Lian et al. Int J Oncol. 2012 [60]. Katsushima et al. J Biol. Chem. 2012 [57] |
miR-1207 | DHCR24, Claudins | DHCR24 expression decreased in metastatic prostate cancer. Claudins. Associated with cell motility and tumour invasion and spread of tumour cells and metastasis. | Romanuik et al. Am J Pathol. 2009 [64]. Webb et al. BMC Cell Biol. 2013 [67] |
miR-139 | RAP1B, c-FOS, IGF1R, TOP2A CXCR4 | RAP1B, family RAS (oncogene). It has a pseudogene. IGF1R Low expression of miR in colo-rectal cancer is associated to more advanced tumours and less survival. FOS proteins are implicated in cell cycle, differentiation and cellular transformation. Dowregulation induces increase in apoptosis and more cellular differentiation. TOP2A, topoisomerase. Upregulation is associated to tumour proliferation. CXCR4, associated with progression and metastasis in CRC. Regulated by HER2-CD44 via miR139. | Guo et al. Cell Biology. 2012 [56]. Milde-Langosch et al. Breast Cancer Res Treat. 2013 [61]. Shen et al. Biochemical Pharmacology. 2012 [65]. Fan et al. Cell Biochem Funct. 2012 [55]. Bao et al. Gastroenterology. 2011 [52] |
miR-92b | PSMD10, FOX2 | PSMD10 . Inhibition of the protein will slow down tumour progression in hepatocarcinoma. High increased expression related to worse prognostic in glioma. FOX2. RNA-binding protein regulates alternative splicing. | Leidner et al. PlosOne. 2013 [59]. He et al. Nature. 2005 [15]. Qian et al. Gastroenterology. 2012 [63] |