Table 1 Clinical tumour characteristics of the sample groups used in the present study
From: MicroRNA profile in very young women with breast cancer
|  | Discovery set N = 34 (%) | Validation set N = 55 (%) | |||
|---|---|---|---|---|---|
Age group | <35 (n = 22)* | >65 (n = 12) | <35 (n = 21) | 45-65 (n = 17) | >65 (n = 17) |
Age mean (SD) | 31.41 (4.04) | 73.3 (10.18) | 31.4 (2.87) | 56.94 (5.58) | 69.4 (4.48) |
BMI mean (SD) | 21.98 (3.53) | 29.44 (6.66) | 23.95 (5.50) | 30.15 (8.04) | 30.23 (6.55) |
Histological grade | Â | Â | Â | Â | Â |
 I | 1 (4.55) | 3 (25.00) | 3 (14.29) | 8 (47.06) | 3 (17.65) |
 II | 8 (36.36) | 3 (25.00) | 7 (33.33) | 5 (29.41) | 12 (70.59) |
 III | 13 (59.09) | 6 (50.00) | 11 (52.38) | 4 (23.53) | 2 (11.76) |
Histological Type | Â | Â | Â | Â | Â |
 Ductal | 19 (86.36) | 11 (91.67) | 19 (90.48) | 13 (76.47) | 12 (70.59) |
 Lobular | 0 (0.00) | 0 (0.00) | 1 (4.76) | 0 (0.00) | 2 (11.76) |
 Others | 3 (13.64) | 1 (8.33) | 1 (4.76) | 4 (23.53) | 3 (17.65) |
Tumour size | Â | Â | Â | Â | Â |
 < 2 cm | 3 (13.64) | 9 (75.00) | 3 (14.29) | 11 (4.71) | 14 (82.35) |
 2-5 cm | 15 (68.18) | 2 (16.67) | 15 (71.43) | 6 (35.29) | 3 (17.65) |
 > 5 cm | 4 (18.18) | 1 (8.33) | 3 (14.29) | 0 (0.00) | 0 (0.00) |
Nodal status | Â | Â | Â | Â | Â |
 Positive | 10 (45.45) | 4 (33.33) | 7 (33.33) | 6 (35.29) | 3 (17.65) |
 Negative | 12 (54.55) | 8 (66.67) | 14 (66.67) | 11 (64.71) | 14 (82.35) |
Receptors | Â | Â | Â | Â | Â |
 ER+ | 17 (77.27) | 9 (75.00) | 14 (66.67) | 14 (82.35) | 14 (82.35) |
 ER - | 5 (22.73) | 3 (25.00) | 7 (33.33) | 3 (17.65) | 3 (17.65) |
 PR+ | 15 (68.18) | 7 (58.33) | 14 (66.67) | 13 (76.47) | 13 (76.47) |
 PR - | 7 (31.82) | 5 (41.67) | 7 (33.33) | 4 (23.53) | 4 (23.53) |
 HER2+ | 10 (45.45) | 3 (25.00) | 5 (23.81) | 2 (11.76) | 2 (11.76) |
 HER2 - | 12 (54.55) | 9 (75.00) | 16 (76.19) | 15 (88.24) | 15 (88.24) |
Ki67 | Â | Â | Â | Â | Â |
 1-14% | 5 (22.73) | 3 (25.00) | 5 (23.81) | 8 (47.06) | 5 (29.41) |
 14-30% | 8(36.36) | 5 (41.67) | 11 (52.38) | 7 (41.18) | 10 (58.82) |
 >30% | 9 (40.91) | 4 (33.33) | 5 (23.81) | 2 (11.76) | 2 (11.76) |
Histological subtype | Â | Â | Â | Â | Â |
 Luminal A | 5 (22.73) | 3 (25.00) | 3 (14.29) | 8 (47.06) | 5 (29.41) |
 Luminal B | 6 (27.27) | 4 (33.33) | 10 (47.62) | 4 (23.53) | 9 (52.94) |
 TN | 2 (9.09) | 2 (16.67) | 3 (14.29) | 3 (17.65) | 2 (11.76) |
 Luminal/HER2 | 5 (22.73) | 2 (16.67) | 2 (9.52) | 0 (0.00) | 1 (5.88) |
 HER2 | 4 (18.18) | 1 (8.33) | 3 (14.29) | 2 (11.76) | 0 (0.00) |